grant
Engineering Tunable Biomimetic Adhesive Hydrogel to Deliver and Enhance MSC Function for Corneal Regeneration
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAccelerationAcidsAddressAdherenceAdhesionsAdhesivesAffectAnhydridesAnimal ModelAnimal Models and Related StudiesBandageBiocompatible MaterialsBiological MimeticsBiomaterialsBiomechanicsBiomimeticsBlindnessBody TissuesCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell secretionCell-Extracellular MatrixCellsCellular ProliferationCellular SecretionChemicalsCicatrixClient satisfactionClinicalCorneaCornea TransplantationCorneal DiseasesCorneal DisorderCorneal GraftingCorneal InjuryCorneal TransplantationDataDefectDevelopmentDiminished VisionECMEncapsulatedEngineeringEnvironmentEpitheliumExtracellular MatrixEyeEye InjuriesEye diseasesEyeballFailureFibrinFibrosisFormulationFrictionGelGelatinGeneralized GrowthGoalsGrowthHealthHealth Care SystemsHyaluronic AcidHybridsHydrogelsImpairmentIn VitroIn vivo analysisInflammationInjectionsInjuryKeratoplastyLeannessLow VisionMedicalMembraneMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethacrylatesMethodsModelingOcular InjuryOutcomePartial SightPathologicPatient SatisfactionPatientsPolymersProgenitor CellsProliferatingPropertyPublic HealthQOLQOL improvementQuality of lifeReduced VisionReportingScarsSightStructureSubnormal VisionSurfaceSurgical suturesSuturesSwellingSystemTechnologyTherapeutic EffectThinnessTimeTissue GrowthTissuesUlcerUlcerationUnited StatesViscosityVisionVisualVisual disabilityVisual impairmentVisually disabledWound RepairWound modelsbiological materialbiomechanicalchemical propertyconventional therapyconventional treatmentcornea disordercornealcorneal epithelialcorneal epithelial wound healingcorneal epitheliumcorneal healingcorneal keratoplastycorneal regenerationcorneal repaircorneal transplantcorneal woundcorneal wound healingcritical injurycrosslinkdevastating injurydevelopmentaldosageepithelium regenerationeye disordereye traumahealingimprovedimprovements in QOLimprovements in quality of lifein vitro Modelin vivoin vivo evaluationin vivo testinginfection riskinjuriesmechanical propertiesmeltingmembrane structuremesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsminimally invasivemodel of animalneovascularizationnovelocular diseaseocular disorderocular surfaceocular traumaontogenyophthalmopathyphysical propertypolymerpolymericpreventpreventingprogenitor Cell growthprogenitor cell based therapyprogenitor cell deliveryprogenitor cell differentiationprogenitor cell functionprogenitor cell migrationprogenitor cell survivalprogenitor cell therapyprogenitor cell treatmentprogenitor deliveryprogenitor differentiationprogenitor functionprogenitor growthprogenitor migrationprogenitor survivalprogenitor therapyprogenitor treatmentquality of life improvementre-epithelializationregenerate epitheliumregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissuerepairrepairedresponsesealsevere injuryside effectstem and progenitor cell functionstem and progenitor cell therapystem and progenitor differentiationstem and progenitor functionstem cell based therapystem cell deliverystem cell differentiationstem cell functionstem cell growthstem cell mediated therapystem cell migrationstem cell survivalstem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellsstromal progenitorstromal stem celltherapeutic outcometherapy outcomethree dimensionaltissue regenerationtissue regrowthtissue renewaltissue repairtissue specific regenerationtissue woundvision disabilityvision impairmentvision lossvisual functionvisual lossvisually impairedwoundwound healingwound healing modelswound recoverywound resolutionwoundingwounds
Description preview
Project Summary
Corneal diseases pose a significant public health challenge in the United States, often leading to vision
impairment and decreased quality of life. Mesenchymal stem cell (MSC) delivery to the cornea after a severe
injury has shown promise by accelerating repair and significantly suppressing inflammation. However, a major
bottleneck…
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