grant
Engineering radical enzymes for asymmetric olefin hydroalkylation
Organization MICHIGAN STATE UNIVERSITYLocation EAST LANSING, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAccelerationAlkenesAmino AcidsBiochemicalBiologicalClinicalComplexCrude OilEngineeringEnzyme GeneEnzymesGI microbiomeGenerationsGoalsH-bondHealthHumanHydrogen BondingIn VitroMedicineMethodsMicrobeModern ManMolecularNatureOlefinsOrganic SynthesisPetroleumPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlayReactionResearchRoleRouteShapesSubstrate SpecificityTherapeuticTolueneVariantVariationaminoacidbiologicbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesdesigndesigningdigestive tract microbiomedrug discoveryenteric microbiomeforginggastrointestinal microbiomegene manipulationgenetic manipulationgenetically manipulategenetically perturbgut microbiomegut-associated microbiomehexadecaneinnovateinnovationinnovativeintestinal biomeintestinal microbiomemethyl-benzenenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-Nativenonnativenovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypetroleum oilpharmaceuticalpollutantremediationscaffoldscaffoldingsocial rolesuccesstherapeutic agent developmenttherapeutic developmentthree dimensional
Description preview
PROJECT SUMMARY: The synthesis of biologically active molecules through selective C–C bond-forming
reactions is central to the discovery of new therapeutics. Though forging C–C bonds is often more challenging
at C(sp3)-centers than C(sp2)-centers, especially when new stereocenters emerge, clinical success is correlated
with sp3-richness.…
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