grant
Engineering promiscuous enzymes for synthesis of biological building blocks
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AllyAmino AcidsAssayBioassayBiologicalBiological AssayCarbonCouplingDataDevelopmentDiagnosticDirected Molecular EvolutionEngineeringEnzyme GeneEnzymesIntermediary MetabolismKineticsMedicinal ChemistryMedicineMetabolic ProcessesMetabolismNatureOrganic ChemistryPharmaceutic ChemistryPharmaceutical ChemistryPyridoxal 5-PhosphatePyridoxal PhosphateReactionResearchResolutionSideSolventsSpecificityThermodynamicThermodynamicsaminoacidbiologiccostdesigndesigningdevelopmentaldirected evolutiondriving forceenzyme activityforgingimprovedinsightresolutionsscreeningscreeningsspectroscopic studyspectroscopic surveysynergism
Description preview
The use of enzymes in synthesis has had an enormous impact on the development of bioactive
compounds, as they can perform transformations with unparalleled selectivity at a low cost without
using toxic solvents. However, there is a dearth of enzymes that catalyze C-C bond formation on
preparative scales. Many common enzymes from central metabolism…
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