grant
Engineering Natural Killer Cell Derived Extracellular Vesicular Nanodrug for Tumor Targeted Bioimaging and Therapy
Organization UNIVERSITY OF TEXAS TYLERLocation TYLER, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202514-HydroxydaunomycinAccelerationAdhesion MoleculeAdriamycineAffectAnti-Cancer AgentsAntigen-Presenting CellsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsBiochemicalBiodistributionBiologicalBiological MarkersBiologyBiomedical ResearchBlood monocyteBody TissuesBreastBreast CancerBreast Cancer CellCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCancer DrugCancer TreatmentCancerousCancersCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Surface ReceptorsCell TherapyCell surfaceCellsCellular StressCellular Stress ResponseClinicalCommunicationCytotoxic cellDiseaseDisorderDisseminated Malignant NeoplasmDistantDoxorubicinDoxorubicinaDrug DeliveryDrug Delivery SystemsDrug TargetingDrugsERBB2ERBB2 geneEndothelial CellsEngineeringEstrogensExhibitsFatsFatty acid glycerol estersGenetic MaterialsHER -2HER-2HER2HER2 GenesHER2/neuHeterogeneityHeterograftHeterologous TransplantationHistocompatibility ComplexHistocompatibility ComplicesHost DefenseHumanHybridsHydroxyl DaunorubicinHydroxyldaunorubicinImageImmuneImmune SurveillanceImmunesImmunodeficient MouseImmunologic SurveillanceImmunosurveillanceImplantIn vivo analysisInfectionInnate Immune SystemIntegrin alphaLbeta2K lymphocyteKnowledgeLYT3Large granular lymphocyteLeukocyte Function Associated Antigen-1LipidsLiposomalLiposomesLiquid substanceLymphocyte Function-Associated Antigen-1MCF-10AMCF-7MCF-7 CellMCF-7DRMCF-7WTMCF10AMCF10A cellsMCF7MCF7 cellMDA MB 231MDA-231MDA-MB231MacrogolsMacrophageMajor Histocompatibility ComplexMajor Histocompatibility ComplicesMalignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMarrow monocyteMedicationMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModern ManMolecularMonitorMurineMusMφNEU OncogeneNEU proteinNIR dyeNIR imagingNIR optical imagingNK CellsNatural Killer CellsNear-infrared Fluorescence ImagingNear-infrared optical imagingNeoplasm MetastasisNeoplastic Disease Chemotherapeutic AgentsOncogene ErbB2OrganOutcomePR PositiveParentsPeer ReviewPeripheral Blood LymphocytePharmaceutical PreparationsPlayPolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolyoxyethylenesPrecision cancer therapyPrecision cancer treatmentPrimary NeoplasmPrimary TumorProductionPropertyProteinsProteomicsPublicationsPublishingReceptor ProteinReportingResearchRoleScientific PublicationSecondary NeoplasmSecondary TumorSiteSpecificityStudentsSurfaceSurvey InstrumentSurveysSystemT4 CellsT4 LymphocytesTKR1TestingTherapeuticTherapeutic EstrogenTissuesTumor-Specific Treatment AgentsXenograftXenograft procedureXenotransplantationaccessory cellanimal imaginganti-canceranti-cancer druganti-cancer therapybio-imagingbio-markersbiocompatibilitybioimagingbiologicbiologic markerbiomarkerbiomaterial compatibilitybreast tumor cellc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer cellcancer metastasiscancer therapycancer-directed therapycareercell adhesion proteincell based interventioncell mediated interventioncell mediated therapiescell stresscell-based therapeuticcell-based therapycellular therapeuticcellular therapyclinical translationclinically translatablecomplex biological systemsdesigndesigningdrug/agentengineered NK cellengineered natural killer cellerbB-2 Genesexperienceextracellularextracellular vesiclesfluidherstatinimage guidanceimage guidedimagingimaging agentimprovedin vivo evaluationin vivo testinginterestliquidmalignancymalignant breast tumormammarymicrobialmonocytenano medicinalnano medicinenanodrugnanomedicinalnanomedicinenanopharmaceuticalnanosystemsnear IR dyenear infrared dyenear infrared imagingneoplasm/cancerneu Genesparentperipheral bloodpersonalized drugspre-clinical studyprecision anticancer therapyprecision cancer therapeuticprecision drugspreclinical studyprogesterone receptor positiveprogramsreceptorresponse to therapyresponse to treatmentskillssocial roletargeted biomarkertherapeutic responsetherapy responsetreatment responsetreatment responsivenesstumortumor cell metastasisuptakevesicle releasevesicular releasexeno-transplantxeno-transplantation
Description preview
Natural Killer (NK) cells are large granular lymphocytes that belong to the innate immune system, and their major
function is to provide host defense against microbial infections and tumors by immune surveillance of the cell
surface to find the abnormal expression of major histocompatibility complex (MHC) class I molecules and cell
stress markers.…
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