grant
Engineering lipid nanoparticle platform for selective and enhanced delivery in vivo
Organization UNIVERSITY OF NEVADA LAS VEGASLocation LAS VEGAS, UNITED STATESPosted 7 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAffectAgonistBiochemicalBiodistributionBody TissuesCell BodyCellsCharacteristicsDiseaseDisorderEncapsulatedEndosomesEngineeringExtrahepaticFormulationGenetic DiseasesGoalsImmuneImmune systemImmunesImmunomodulationKnowledgeLigandsLipidsLiverLymphatic cellLymphocyteLymphocyticMessenger RNAModificationPancreasPancreaticPerformancePlasma ProteinsProductionPropertyProtein Replacement TherapyProteinsReceptor ProteinReceptosomesResearchRibosomesSiteSurfaceSurface PropertiesSystemTechnologyTherapeuticTissuesViralWorkcell typeclinical applicabilityclinical applicationdeliver mRNAdeliver messenger RNAdelivery system for mRNAdelivery vectordelivery vehicledesigndesigningenzyme replacement therapyenzyme replacement treatmentgenetic conditiongenetic disorderhepatic body systemhepatic organ systemimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedin vivoinnovateinnovationinnovativelipid based nanoparticlelipid nanoparticlelymph cellmRNAmRNA deliverymessenger RNA deliverynano particlenano-sized particlenanoparticlenanosized particlenext generationprogramsprotein expressionreceptorresponsesmall moleculetrafficking
Description preview
Project Summary
The long-term goal of my independent research program is to develop robust LNP platforms for treating genetic
diseases and protein replacement therapies. Lipid nanoparticles (LNP) have emerged as a promising technology
for mRNA delivery without the drawbacks associated with viral delivery. Despite this progress, a major hurdle…
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