grant
Engineering ingestible nanosensors for breath-based detection of colorectal cancer
Organization GEORGIA INSTITUTE OF TECHNOLOGYLocation ATLANTA, UNITED STATESPosted 15 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026Accuracy of DiagnosisAddressAdherenceAffectAngiogenesis FactorAngiogenic FactorAnimal ModelAnimal Models and Related StudiesAssayBar CodesBenignBioassayBioavailabilityBiodistributionBioinformaticsBiological AssayBiological AvailabilityBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesBreath TestsCRC screeningCancer CauseCancer EtiologyCancersCarbohydratesCell Communication and SignalingCell SignalingCell-Extracellular MatrixCessation of lifeChemistryClassificationClinicalColitisColonColonoscopyColorectal CancerDataData SetDeathDetectionDevelopmentDiagnosisDiagnosticDiagnostic testsDietDiffusionDiseaseDisorderDistantDropsDrug KineticsDrugsECMEarly DiagnosisEncapsulatedEngineeringEnzyme GeneEnzymesEsteroproteasesExhalationExhalingExposure toExtracellular MatrixFluorogenic SubstrateFormulationFunctional MetagenomicsGlycohydrolasesGlycosidasesGlycoside HydrolasesGrowth AgentsGrowth FactorGrowth SubstancesHumanIn VitroIndividualIntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingKineticsLibrariesLungLung Respiratory SystemMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedical Care CostsMedicationMetagenomicsMiceMice MammalsModern ManMonitorMorphologyMurineMusNon-Invasive DetectionNoninvasive DetectionOncogenesisOralPathologyPathway interactionsPeptidasesPeptide HydrolasesPeptidesPharmaceutical PreparationsPharmacokineticsPhysiologic AvailabilityPlayProductionProtease GeneProteasesProteinasesProteins Growth FactorsProteolytic EnzymesPulmonary Gas ExchangeReactionRecommendationReporterRespiratory DiseaseRespiratory ExpirationRespiratory System DiseaseRespiratory System DisorderRoleSamplingSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSiteSpecificityStomachSurfaceSurvival RateSystematicsTestingTimeTissuesTumor Cell InvasionTumor InvasionTumor PromotionUnited StatesValidationVisualizationVolatilizationWorkadherence ratebarcodebio-markersbiologic markerbiological signal transductionbiomarkerbiomarker discoverybiomarker identificationbiomarker signaturebowelbreath analysiscancer classificationcohortcolorectal cancer detectioncolorectal cancer early detectioncolorectal cancer screeningcontrolled releasedesigndesigningdetect colorectal cancerdevelopmentaldiagnostic accuracydiagnostic platformdiagnostic systemdietsdiffuseddiffusesdiffusingdiffusionsdrug/agentearly biomarkersearly detectionearly detection biomarkersearly detection markersenzyme activityfecal samplegastricgenotoxicityhuman modelidentification of biomarkersidentification of new biomarkersimprovedintestinal epitheliummachine learned algorithmmachine learning algorithmmachine learning based algorithmmalignancymarker identificationmedical costsmedical expensesmicrobiomemodel of animalmodel of humanmolecular scalemouse modelmurine modelnano medicinalnano medicinenano-sized sensorsnanocarriernanomaterialsnanomedicinalnanomedicinenanosensingnanosensorsnanovesselneoplasm/cancernon-invasive diagnosisnon-invasive diagnosticnoninvasive diagnosisnoninvasive diagnosticpathwayrecommended screeningresponse to therapyresponse to treatmentscreeningscreening guidelinesscreening recommendationsscreeningssensorsocial rolestool samplestool specimensuccesstechnology platformtechnology systemtherapeutic responsetherapy responsetranscriptomicstreatment responsetreatment responsivenesstumortumorigenesisvalidationsvolatile organic chemicalvolatile organic compound
Description preview
Project Summary/Abstract
Colorectal cancer is the second leading cause of cancer death in the United States, and early
detection is key to reducing the 53,000 deaths per year. Current screening relies on tests for fecal
biomarkers, which have good sensitivity for advanced-stage CRC but poor sensitivity for early-
stage CRC. For this reason, direct…
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