grant
Engineering cell-based therapy for enhanced survival and durable function in vivo
Organization MAYO CLINIC ARIZONALocation SCOTTSDALE, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025Allogeneic TransplantationAttentionBiologicalBiomedical EngineeringBlack BoxCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCell TherapyCell TransplantationCell secretionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular SecretionCessation of lifeChronic DiseaseChronic IllnessCuesDeathDevicesDiabetes MellitusDiseaseDisorderDrugsDysfunctionEncapsulatedEngineeringEnvironmentFactor VIII DeficiencyFibrosisForeign-Body ReactionFunctional disorderFutureGoalsHeartHemophiliaHemophilia AHepatic DisorderHomologous TransplantationHumanHypoxiaHypoxicImmune systemImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImplantKnowledgeLiverLiver diseasesMedicationModern ManOrganOxygen DeficiencyPathway interactionsPharmaceutical PreparationsPhysiopathologyResearchSubcellular ProcessSystemTherapeuticbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringcell based interventioncell behaviorcell engineeringcell mediated interventioncell mediated therapiescell resiliencecell resiliencycell-based therapeuticcell-based therapycellular behaviorcellular engineeringcellular resiliencecellular resiliencycellular therapeuticcellular therapycellular transplantchronic disorderclinical translationclinically translatablecombatdesigndesigningdiabetesdrug/agenthepatic body systemhepatic diseasehepatic organ systemhepatopathyimmune suppressionimmune suppressive activityimmune suppressive functionimmunogenicimmunogenicityimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinflammatory environmentinflammatory milieuinnovateinnovationinnovativeliver disordermultidisciplinarynative protein drugnecrocytosispathophysiologypathwaypharmaceutical proteinprogramsprotein drug agentprotein-based drugtherapeutic protein
Description preview
Project Summary
The long-term goal of my lab is to develop durable cell-based therapies for treating various chronic diseases.
Engineered cells secreting therapeutic proteins are grafted into the body to act as biological drug-factories and
provide an attractive strategy for long-term cure of diseases such as hemophilia, diabetes, and liver…
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