grant
Engineering Biologics for treatment of enteric diseases
Organization TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRLocation COLLEGE STATION, UNITED STATESPosted 30 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025ANK DomainANK RepeatAccelerationAcute DiarrheaAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAnkyrin RepeatAnkyrin Repeat DomainAntibiotic AgentsAntibiotic DrugsAntibioticsAntibodiesBacteriaBindingBiologicalBiological AgentBiological ProductsBiological Response Modifier TherapyBiological TherapyBiomedical EngineeringBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBovine SpeciesC diffC difficileC. diffC. difficileCancersCapsid ProteinsCattleChronic diarrheaClostridioides difficileClostridium difficileCoat ProteinsCodeCoding SystemColostrumComplementary DNAConstipationCoupledCustomD2E7 antibodyDNA mutationDevelopmentDiarrheaDiffusionDigestionDigestive TractDirected Molecular EvolutionDiseaseDisorderDrug Side EffectsDrugsE coliE. coliEngineered ProbioticsEngineeringEnteralEntericEnvironmentEscherichia coliEsteroproteasesExhibitsFoodGI TractGastrointestinal TractGastrointestinal tract structureGenerationsGenetic ChangeGenetic defectGenetic mutationHealthHomeHospital AdmissionHospitalizationHumanIn SituIn VitroInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderInjectionsLibrariesLinkMalignant NeoplasmsMalignant TumorMediatingMedicationMessenger RNAMicrobeMiscellaneous AntibioticModelingModern ManModified ProbioticsMolecular InteractionMutationOralPatientsPeptidasesPeptide HydrolasesPeptide Signal SequencesPeptidesPersonsPhage DisplayPharmaceutical PreparationsPopulationPositionPositioning AttributePredispositionPrevalenceProbiotic EngineeringProbioticsProtease GeneProteasesProtein SecretionProteinasesProteinsProteolytic EnzymesRNA NucleasesRNaseReactionResistanceRibonuclease Family ProteinRibonucleasesRibosomesScaffolding ProteinSepsisSignal PeptideSignal SequencesSusceptibilitySymptomsSystemic diseaseTechnologyToxinTripcellimTrypsinVariantVariationViralViral Coat ProteinsViral Outer Coat ProteinVirulentYeastsadalimumabalimentary tractbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbiological therapeuticbiological treatmentbiologically based therapeuticsbiologicsbiopharmaceuticalbiotherapeutic agentbiotherapeuticsbiotherapybovidbovinecDNAchymotrypsincowcustomsdesigndesigningdevelopmentaldiarrheal diseasediarrheal illnessdiffuseddiffusesdiffusingdiffusionsdigestive canaldirected evolutiondisease durationdisease lengthdrug/agentengineering designgenome mutationhomesillness lengthimprovedin vivoinfection riskinflammatory disease of the intestineinflammatory disorder of the intestineintestinal autoinflammationmRNAmalignancymicroorganismmodel of animalneoplasm/cancernovelpre-clinical developmentpreclinical developmentpreventpreventingpromoterpromotorprotein signal sequenceresistantscaffoldscaffoldingside effectstandard of caresynergismthermolabilitythermostability
Description preview
Abstract
Enteric diseases, including both acute and chronic diarrhea and constipation, are among the most common
ailments afflicting humans. Many enteric diseases, such C. difficile infection (CDI) and inflammatory bowel
disease (IBD), are currently treated with systemically delivered biologics (e.g. bezlotoxumab for CDI and anti-
TNF antibodies…
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