grant
Engineered probiotic for the treatment of autoimmune diseases
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 20 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026(TNF)-α16S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAcidsAddressAffectAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayAtrophic ArthritisAutoimmune DiseasesBacteriaBioassayBiodistributionBiological AgentBiological AssayBiological ProductsBiological Response Modifier TherapyBiological TherapyBiomedical EngineeringBloodBlood Reticuloendothelial SystemBody TissuesCachectinCapsulesCaringCell BodyCellsCessation of lifeChromosomesCirculationClinicalClinical TrialsCollagen ArthritisCollagen-Induced ArthritisCommon Rat StrainsDeathDigestive TractDiseaseDisorderDisseminated SclerosisDoseDrug KineticsDrugsDysfunctionELISAElectrophysiologyElectrophysiology (science)Engineered ProbioticsEngineeringEnteralEntericEnzyme-Linked Immunosorbent AssayEpitheliumFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGI TractGI microbiomeGastrointestinal TractGastrointestinal tract structureGenesGoalsGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHistologyHumanIMiDImmune RegulatorsImmune modulatory therapeuticImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunomodulationImmunomodulatorsIn VitroInjectionsIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesIntracellular Second MessengerJointsK channelL reuteriL. reuteriLactobacillus reuteriMacrophage-Derived TNFMarketingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicationMemoryModelingModern ManModified ProbioticsMonocyte-Derived TNFMultiple SclerosisNIAIDNational Institute of Allergy and Infectious DiseaseNatureNeurophysiology / ElectrophysiologyOralOral AdministrationOral Drug AdministrationOrganoidsPathologyPatient CarePatient Care DeliveryPatient CompliancePatientsPeptidesPersonsPharmaceutical PreparationsPharmacokineticsPhasePhysiopathologyPopulationPotassium ChannelPotassium Ion ChannelsProbiotic EngineeringProbioticsProductionPropertyR-Series Research ProjectsR01 MechanismR01 ProgramRadiographyRatRats MammalsRattusRecombinantsResearch GrantsResearch Project GrantsResearch ProjectsRheumatoid ArthritisRodentRodentiaRodents MammalsRoentgenographySafetySecond Messenger SystemsSecond MessengersSeveritiesSymptomsT memory cellT-Cell ActivationT-Cell ProliferationT-CellsT-LymphocyteTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTherapeuticTissuesTumor Necrosis FactorTumor Necrosis Factor-alphaVenomsWestern BlottingWestern ImmunoblottingWorkactivate T cellsadductalimentary tractanalogautoimmune conditionautoimmune disorderautoimmunity diseasebio-engineeredbio-engineersbioengineeringbiological engineeringbiological therapeuticbiological treatmentbiologically based therapeuticsbiologicsbiopharmaceuticalbiotherapeutic agentbiotherapeuticsbiotherapybonebowelcapsulecare for patientscare of patientscaring for patientschronic autoimmune diseasecytokinedigestive canaldigestive tract microbiomedrug/agentdysbacteriosisdysbiosisdysbioticelectrophysiologicalenteric microbiomeenzyme linked immunoassayflow cytophotometrygastrointestinal microbiomegut microbiomegut-associated microbiomehealthy volunteerimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulationimmune modulatorsimmune modulatory agentsimmune modulatory drugsimmune regulationimmunogenicityimmunologic reactivity controlimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatoryimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory moleculesimmunomodulatory therapeuticsimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimprovedin vivoinsular sclerosisintestinal biomeintestinal microbiomeintraoral drug deliverylymph organlymphatic organlymphoid organmemory T lymphocytemicrobial imbalancemodel of animalmultidisciplinarynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnon-human primatenonhuman primatenovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathophysiologypatient adherencepatient cooperationpilot trialpreventpreventingpristane induced arthritisprobiotic therapeuticprobiotic therapyprobiotic treatmentprofound disabilitypromoterpromotorprotein blottingradiological imagingrecombinant peptideresponserheumatic arthritisserious disabilitysevere disabilityside effectsignal transduction second messengerstherapeutic evaluationtherapeutic testingthymus derived lymphocytetreatment strategy
Description preview
PROJECT SUMMARY
Approximately 50 million people suffer from one or more autoimmune diseases in the US alone. Over the
last decades, the discovery of biologics has considerably improved the care for patients with autoimmune
diseases. However, current treatments require weekly or more frequent injections and this can lead to missed
doses and to…
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