grant
Endosomal Platforms for Signaling Pain
Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 15 Aug 2017Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025A5 AntigenAbsence of pain sensationAbsence of sensibility to painAffectAnatomic SitesAnatomic structuresAnatomyArtificial nano particlesArtificial nanoparticlesAssayBehaviorBindingBioassayBiological AssayBioluminescenceBiophysicsBiosensorCalcitoninCalcitonin Gene-Related PeptideCalcitrinCancersCell Communication and SignalingCell SignalingCell Surface ReceptorsCell membraneCell modelCell surfaceCellular modelChaperoneClinicalClinical Treatment MoabConfocal MicroscopyCytoplasmic MembraneDephosphinDiseaseDisorderDorsal Root GangliaDrugsDynaminElectrophysiologyElectrophysiology (science)EncapsulatedEndocytosisEndocytosis InductionEndosomesEnergy TransferEsteroproteasesExhibitsFRETFamilyFeels no painFluorescence Resonance Energy TransferFundingFörster Resonance Energy TransferG Protein, Alpha-Interacting ProteinG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingG-Protein-Coupled ReceptorsGAIPGP80-LNGFRGPCRGPCR SignalingGRIK1 gene productGlutamatesGrowth AgentsGrowth FactorGrowth SubstancesHumanImageImmunofluorescenceImmunofluorescence ImmunologicIn Situ HybridizationInflammationIntracellular Communication and SignalingKinasesL-GlutamateLifeLigandsLipidsLiteratureLong-term painLow-Affinity Nerve Growth Factor ReceptorMalignant NeoplasmsMalignant TumorMediatingMediatorMedicalMedicationMembraneMessenger RNAMiceMice MammalsModern ManMolecular ChaperonesMolecular InteractionMonoclonal AntibodiesMurineMusNGF ReceptorNGFR ProteinNK-1 ReceptorsNK1RNKIRNRP1 ProteinNerve CellsNerve Growth Factor ReceptorNerve Growth Factor Receptor p75Nerve Growth FactorsNerve UnitNeural CellNeural TransmissionNeurocyteNeurokinin-1 ReceptorsNeuronotrophic FactorsNeuronsNeurophysiology / ElectrophysiologyNeuropilin-1Neurotrophic ProteinsNeurotropin Receptor p75No sensitivity to painNociceptionNociceptorsNpn-1 ProteinOpiate ReceptorsOpiatesOpioidOpioid ReceptorOrganism-Level ProcessOrganismal ProcessPTK ReceptorsPainPain ControlPain TherapyPain managementPainfulPathologic ProcessesPathological ProcessesPathologyPeptidasesPeptide HydrolasesPersistent painPharmaceutical PreparationsPhosphotransferase GenePhosphotransferasesPhysiologic ProcessesPhysiological ProcessesPlasma MembranePopulationProcessProtease GeneProteasesProteinasesProteinsProteins Growth FactorsProteolytic EnzymesRGS19RGS19 geneRGSGAIPReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor SignalingReceptor Tyrosine Kinase GeneReceptosomesRecombinant ProteinsRegulator of G-Protein Signaling 19RoleSP-P ReceptorsScaffolding ProteinSema III ReceptorSemaphorin III ReceptorSignal TransductionSignal Transduction SystemsSignalingSpinalSpinal GangliaSubstance P ReceptorSurfaceSynaptic TransmissionSynaptic VesiclesTAC1RTACR1TACR1 geneTachykinin Receptor 1TestingThyrocalcitoninTransmembrane Receptor Protein Tyrosine KinaseTransmissionTransphosphorylasesTropomyosinTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsVEGFVEGFsVascular Endothelial Cell Growth Factor 165 ReceptorVascular Endothelial Growth FactorsVesicleabuse liabilityabuse potentialadverse consequenceadverse outcomeanalgesiaantagonismantagonistbehavior studybehavioral studybiological sensorbiological signal transductionbiophysical analysisbiophysical approachesbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical studiesbiophysical techniqueschronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentconstant paindesigndesigningdorsal root gangliondrug discoverydrug/agentefficacious therapyefficacious treatmentelectrophysiologicalengineered nano particleengineered nanoparticleextracellularglutamatergicgp75 NGFRimagingimaging studyimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodinflammatory paininhibitorinsightlasting painmAbsmRNAmalignancymembrane structuremetabotropic glutamate receptor 5monoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernerve injuryneural injuryneuronalneuropathic painnociceptivenociceptive neuronsnon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicson-going painongoing painp75 neurotrophin receptorp75NTRpain interventionpain reliefpain signalpain treatmentpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainful neuropathyplasmalemmaprotein protein interactionreceptorrelieve painretrograde transportscaffoldscaffoldingside effectsocial roletherapeutic targettraffickingtransmission processtreat chronic pain
Description preview
PROJECT SUMMARY/ABSTRACT
G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are mediators of and
therapeutic targets for diverse disorders, including chronic pain. This proposal challenges the
dogmas that these receptors signal primarily from the plasma membrane and that cell surface
receptors are the optimal therapeutic…
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