grant
Endoplasmic Reticulum Stress in the function of cancer associated fibroblasts in pancreatic cancer
Organization HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCESLocation EAST LANSING, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY20253-10C3D cell culture3D cultureAMCF-IATF6ATF6 geneAblationActivating Transcription Factor 6Animal ModelAnimal Models and Related StudiesBiochemicalBiologyBody TissuesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCXCL8CancerousCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseChemicalsChemotactic CytokinesDataDevelopmentDiseaseDisorderECMER stressEndoplasmic ReticulumErgastoplasmExtracellular MatrixFibroblastsFibrosisGCP1Generalized GrowthGeneticGoalsGrowthGrowth AgentsGrowth FactorGrowth SubstancesHomologous Chemotactic CytokinesHumanIL-8IL8IL8 geneImmuneImmune infiltratesImmune systemImmunesImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIntercrinesIntracellular Communication and SignalingK60LYT3LesionLinkMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMapsMediatingMembraneMiceMice MammalsModelingModern ManMurineMusOncogenesisPDA modelPDAC ModelPDAC cancer cellPDAC cellPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreas NeoplasmsPancreas TumorPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPancreatic TumorPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePhysiologicPhysiologicalProductionProliferatingProteinsProteins Growth FactorsRoleSCYB8SIS cytokinesSecretory CellSignal TransductionSignal Transduction SystemsSignalingSpatial DistributionSubcellular ProcessSurvival RateSystemT8 CellsT8 LymphocytesTSG-1TestingTissue GrowthTissuesTumor PromotionXBP1XBP1 geneaberrant folded proteinaberrant folded proteinsabnormal folded proteinabnormal folded proteinsarmb-ENAPbiological signal transductioncancer microenvironmentcancer progressioncell stresschemoattractant cytokinechemokinecompare to controlcomparison controlcytokinedevelop therapydevelopmentalendoplasmic reticulum stressimmune cell infiltrateimmune competentimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimprovedin vivoinhibitorinnovateinnovationinnovativeinsightintervention developmentknock-downknockdownmalignancymembrane structuremisfolded proteinmisfolded proteinsmodel of animalmouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionontogenypancreatic cancer modelpancreatic ductal adenocarcinoma cellpancreatic ductal adenocarcinoma modelpancreatic malignancypancreatic neoplasiapancreatic neoplasmpancreatic tumor modelpathwaypatient oriented outcomesprecancerprecancerouspremalignantprogramsproteotoxic proteinproteotoxinrecombinaseresponsescRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapy developmentthree dimensional cell culturetransplant modeltreatment developmenttumortumor growthtumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactionstumorigenesis
Description preview
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a dismal 5-year overall survival
of 13%. Among the reasons for such a poor outlook is the presence of a highly fibrotic and immunosuppressive
microenvironment, characterized by activation and expansion of fibroblasts and their extracellular matrix (ECM).…
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