grant
Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Sept 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026Active OxygenAcuteAdvisory CommitteesAntibodiesAntigen PresentationAssayAutoimmuneAutoregulationBacterial InfectionsBioassayBiological AssayBiological MarkersBody TissuesCareer ChoiceCareer PathCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCellular StressCellular Stress ResponseCessation of lifeChIP assayChronicClinical ResearchClinical StudyCo-cultureCocultivationCocultureCoculture TechniquesColitisCommittee MembersCommunitiesCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCytokine GeneDataDeathDevelopment PlansDisease ManagementDisorder ManagementDoctor of MedicineDoctor of PhilosophyER stressEdodekin AlfaEnsureEpithelial CellsExhibitsFellowshipFibrosisFrequenciesFunctional MetagenomicsFundingGI microbiomeGWA studyGWASGastroenterologyGene ExpressionGene TranscriptionGeneticGenetic TranscriptionGoalsGrantGranulomatous EnteritisHomeostasisHumanIL-12IL-23IL12ImmuneImmunesImmunologyInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInnate ImmunityInterleukin-12IntestinalIntestinal FibrosisIntestinesInvestigatorsKnowledgeKnowledge acquisitionLaboratoriesLinkLymphatic cellLymphocyteLymphocyticLymphoid CellM.D.MediatingMedicineMentorsMentorshipMessenger RNAMetagenomicsMiceMice MammalsMitochondriaModelingModern ManModificationMucosaMucosal TissueMucous MembraneMurineMusNKSFNative ImmunityNatural ImmunityNatural Killer Cell Stimulatory FactorNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityOrganoidsOxygen RadicalsPathogenesisPathogenicityPathway interactionsPatientsPeripheralPh.D.PhDPhysiologicPhysiologicalPhysiological HomeostasisPositionPositioning AttributePro-OxidantsProductionProgram DevelopmentProliferatingProteinsRNARNA ExpressionRNA Gene ProductsReactive Oxygen SpeciesResearchResearch PersonnelResearchersRibonucleic AcidRoleSamplingSeriesStimulusStressSurfaceT-CellsT-LymphocyteTask ForcesTechnical ExpertiseTherapeutic InterventionTissuesTranscriptionUniversitiesWashingtonWorkXBP1XBP1 geneadvisory teambacteria infectionbacterial diseasebio-markersbiologic markerbiomarkerbowelbowel inflammationcareer aspirationcareer developmentcareer interestcareer pathwaycareer trackcell stresschromatin immunoprecipitationclinical significanceclinically significantcohortcolitis mouse modelcolitis murine modelcytokinedigestive tract microbiomedisease modeldisorder modeleleocolitisendoplasmic reticulum stressenteral infectionenteric infectionenteric microbiomeenteric pathogen infectionenteropathogen infectionenteropathogenic infectionexperienceexperimentexperimental researchexperimental studyexperimentsgastrointestinal homeostasisgastrointestinal microbiomegenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygut inflammationgut microbiomegut-associated microbiomehelminth infectionhelminthic infectionhuman dataindividualized managementindividualized patient managementinfected with enteropathogeninfected with helminthinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinstructorinterleukin-23intervention therapyintestinal autoinflammationintestinal biomeintestinal epitheliumintestinal homeostasisintestinal infectionintestinal inflammationintestinal microbiomeintestine infectionlymph cellmRNAmRNA Decaymedical collegemedical schoolsmicrobialmicrobiomemitochondrialmouse colitismouse modelmurine colitismurine modelnovelpathwaypersonalized clinical managementpersonalized disease managementpersonalized managementprecision managementprecision medicineprecision-based medicinepredict responsivenesspredicting responseprogramsregional enteritisresponseresponse biomarkerresponse markersresponse to therapyresponse to treatmentschool of medicineskillssocial rolesuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnical skillstherapeutic responsetherapy responsethymus derived lymphocytetranscriptomicstreatment responsetreatment responsivenesswhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY/ABSTRACT
This application proposes a five-year research career development program focused on innate lymphoid
cells in the pathogenesis and individualized management of inflammatory bowel disease. The applicant, Siyan
Cao, M.D., Ph.D., is an Instructor of Medicine at the Division of Gastroenterology at Washington University
School…
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