grant
Endoplasmic reticulum stress and intestinal inflammation
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 May 2010Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AddressAutoregulationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBacteriaBasal Transcription FactorBasal transcription factor genesBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsDevelopmentDimensionsDiseaseDisorderDistressER stressEnhancer-Binding Protein GATA3EnvironmentEpithelial CellsEpitheliumEquilibriumEventExhibitsGATA-3 factorsGATA-3 proteinGATA-Binding Protein 3GATA3GATA3 geneGATA3 proteinGATA3 transcription factorGI microbiotaGastrointestinal microbiotaGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenetic TranscriptionGermGerm-FreeGoalsHealthHomeostasisIgAImmune responseImmunoglobulin AInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderIntestinalIntestinal DiseasesIntestinal DisorderIntestinal NeoplasiaIntestinal NeoplasmsIntestinal TumorIntestinesIntestines NeoplasmsIntracellular Communication and SignalingLearningLungLung Respiratory SystemMediatingMediatorMicrobeMissionNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesOrganismOutcomePathogenicityPathway interactionsPhenotypePhysiological HomeostasisPlayPopulationProductionPropertyProteinsPublic HealthRNA ExpressionRegulationResearchResearch ProposalsRoleSignal TransductionSignal Transduction SystemsSignalingSterilityT cell differentiationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTh-2 CellTh2 CellsTherapeuticTherapeutic UsesTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesType 2 Helper CellXanthinesbalancebalance functionbiological signal transductionbowelbowel inflammationcellular differentiationcommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentalendoplasmic reticulum stressenteric microbial communityenteric microbiotagastrointestinal microbial floragerm free conditiongut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost responseimmune system responseimmunoresponsein vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinsightintestinal autoinflammationintestinal epitheliumintestinal floraintestinal inflammationintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine diseaseintestine disorderliving systemmicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramultispecies consortianovelpathwayrecruitresponsesocial rolespecific pathogen freesterilethymus derived lymphocytetranscription factor
Description preview
PROJECT SUMMARY/ABSTRACT
Highly secretory intestinal epithelial cells (IEC) are exquisitely sensitive to endoplasmic reticulum (ER) stress
and depend upon the unfolded protein response (UPR) to maintain homeostasis and avoid intestinal inflamma-
tion and neoplasia. Although a dysregulated IEC-associated UPR can directly cause intestinal…
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