grant
Endogenous molecular MRI of creatine as a mediator of adrenergic activation of brown adipose tissue
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 15 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202518-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucoseADP Phosphocreatine PhosphotransferaseATP Creatine PhosphotransferaseAdipocytesAdipose CellAdipose tissueAdrenergic AgentsAdrenergic DrugsAdrenergicsAdult-Onset Diabetes MellitusAgonistAmidesAnimalsArtifactsAutoregulationBAT uncoupling proteinBioenergeticsBody TissuesBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBrown Adipose TissueBrown FatCancersCardiovascular DiseasesCell BodyCell Communication and SignalingCell SignalingCellsChemicalsContrast AgentContrast DrugsContrast MediaCreatineCreatine KinaseCreatine Kinase-BCreatine Kinase-B ChainCreatine PhosphokinaseCreatine SupplementDevelopmentDiabetes MellitusDiagnosisDietEarly DiagnosisEncephalonEnergy ExpenditureEnergy MetabolismEquilibriumFat CellsFatsFatty TissueFatty acid glycerol estersFunctional ImagingGene ModifiedH+ elementHealthHeartHeat ProductionHibernating GlandHigh Fat DietHomeostasisHumanHydrogen IonsImageImpairmentInsulin ResistanceIntermediary MetabolismIntracellular Communication and SignalingIonizing Electromagnetic RadiationIonizing radiationKO miceKetosis-Resistant Diabetes MellitusKnock-outKnock-out MiceKnockoutKnockout MiceLifeLife Style ModificationLipocytesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMeasurementMeasuresMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMethodsMiceMice MammalsMicrodialysisMissionModern ManMolecularMonitorMorphologic artifactsMotionMurineMusMuscleMuscle TissueNIDDMNMR ImagingNMR TomographyNational Institutes of HealthNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclear Magnetic Resonance ImagingNull MouseObese MiceObesityOperative ProceduresOperative Surgical ProceduresOralOver weightOverweightPET/CTPET/CT scanPersonsPhysiologic ImagingPhysiological HomeostasisPreventionProtonsPublic HealthRadiation-Ionizing TotalRadiopaque MediaResearchResolutionRespirationRisk FactorsRodentRodentiaRodents MammalsRoleRouteSalineSaline SolutionSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusSurgicalSurgical InterventionsSurgical ProcedureT2 DMT2DT2DMTechniquesTestingThermogenesisThesaurismosisTimeTissue imagingTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of HealthValidationZeugmatographyadiposeadiposityadult onset diabetesbalancebalance functionbiological signal transductionbrown adipose tissue uncoupling proteincancer typecardiovascular disorderclinical translationclinically translatableco-morbidco-morbiditycomorbiditycorpulencecreatine transporterdesigndesigningdevelopmentaldiabetesdietarydietsdisabilityearly detectionfluorodeoxyglucosegene modificationgenetically modifiedimage-based methodimagingimaging methodimaging modalityimprovedinnovateinnovationinnovativeinsulin resistantinsulin toleranceionizing outputketosis resistant diabeteskinase inhibitorlifestyle modificationmalignancymaturity onset diabetesmetabolic imagingmetabolism disordermitochondrial membrane uncoupling proteinmitochondrial uncoupling proteinmolecular imagingmolecule imagingmuscularneoplasm/cancernovelob/ob mouseobesity interventionobesity therapyobesity treatmentpharmacologicphysiological imagingpositron emission computed tomographypreventpreventingquantitative imagingresolutionsrespiratoryrespiratory mechanismresponsesocial rolespectral imagespectral imageryspectrographspectrum imagespectrum imagerysuccesssurgerytemporal measurementtemporal resolutionthermogenintime measurementtumors in the braintype 2 DMtype II DMtype two diabetesuncoupling protein 1validationswhite adipose tissueyellow adipose tissue
Description preview
ABSTRACT
More than 2 billion people are projected to be overweight and 1 billion to be obese by 2030. In addition to its
specific co-morbidities, obesity is a major risk factor for metabolic diseases and cancer. Emerging approaches
utilizing brown adipose tissue (BAT) activation and thermogenesis have the potential to be safe, effective,…
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