grant
Enabling translation of cancer cell proliferation PET imaging via droplet radiochemistry technology
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AdoptionAmendmentAnimal ExperimentsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsBiological MarkersBody TissuesBreast CancerCancer DrugCancer ModelCancer PatientCancer TreatmentCancerModelCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell Proliferative ActivityCellsCellular ProliferationCellular Proliferation RateClinicClinicalClinical DataClinical ResearchClinical StudyClinical TrialsColon CancerColon CarcinomaCorrelation StudiesCorrosivesCyclic GMPDNADataDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDoseDrug DesignEnsureFDG PETFeedbackFutureGoalsGuanosine Cyclic MonophosphateIND FilingIND applicationIND packageIND submissionImageIn VitroIndividualIndustryInfectionInflammationInvestigational New Drug ApplicationInvestigatorsIsotopesLocationMalignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMitotic IndexMonitorMulti-Institutional Clinical TrialMulti-center clinical trialMulti-site clinical trialMulticenter clinical trialMultisite clinical trialNeoplastic Disease Chemotherapeutic AgentsOncologyOncology CancerOutcomePETPET ScanPET imagingPETSCANPETTPatient CarePatient Care DeliveryPatient RecruitmentsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPerformancePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsPreclinical dataProcessProductionProliferation IndexRad.-PETRadiation ChemistryRadiochemistryReactionReagentResearchResearch PersonnelResearchersS-Phase FractionSelection for TreatmentsSpecificityStatistical CorrelationTechnologyTestingTherapeuticTimeTissuesTracerTrainingTraining ProgramsTranslatingTranslationsTumor CellTumor-Specific Treatment Agentsanaloganimal experimentanti-cancer druganti-cancer therapybio-markersbiologic markerbiomarkercGMPcGMP productioncancer carecancer cellcancer imagingcancer in the coloncancer therapycancer typecancer-directed therapycare for patientscare of patientscaring for patientsclinical translationclinically translatablecommercializationcostdensitydevelopmentalexperimental animalexperimental animalsfluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographyglucose metabolismimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindustrial partnershipindustry partnerindustry partnershipinnovateinnovationinnovativeinterestmalignancymalignant breast tumormanufacturenanoDropletneoplasm/cancerneoplastic cellnovelnucleoside analogoncologic imagingoncology imagingparticipant recruitmentpatient oriented outcomespatient populationpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinical studypreclinical findingspreclinical informationpreclinical studyprototyperecruitresponseresponse to therapyresponse to treatmentscale upselection of treatmentsuccesssynergismtherapeutic responsetherapy responsetherapy selectiontooltranslationtreatment responsetreatment responsivenesstreatment selectiontumortumor growthtumor imaginguptake
Description preview
PROJECT SUMMARY
Despite the widespread use and success of [18F]FDG-PET imaging in oncology, there are many situations where
[18F]FDG cannot be used for diagnosis or treatment monitoring, especially for cancers where there is high
background uptake, low tissue density, or slow-growing tumors. Infection or inflammation frequently leads to
false…
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