grant
Empowering NMR Utilization in Mechanistic Biology: Extending Size Limits and Catalyzing Automation
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAdoptionAutomationBacterial GenesBiologicalBiologyBiomedical ResearchCell Communication and SignalingCell SignalingChemicalsCommunitiesComplexDataDemocracyDevelopmentDevelopment and ResearchEconomicsEngineeringEnvironmentInterventionIntracellular Communication and SignalingKnowledgeLabelMachine LearningManualsMeasurementMethodologyMethodsMinorModernizationMolecular ConfigurationMolecular ConformationMolecular StereochemistryMultidimensional NMR TechniquesNoiseNuclear Magnetic ResonancePhysiologic pulseProtein DynamicsProteinsPulseR & DR&DRelaxationResearchResearch ProposalsResolutionSamplingSeriesSignal TransductionSignal Transduction SystemsSignalingStructureSystemTechniquesTechnologyTimebiologicbiological signal transductionconformationconformationalconformational stateconformationallyconformationsdata acquisitiondata acquisitionsdesigndesigningdevelopmentaldrug developmentdrug discoveryeconomicempowermentexperimentexperimental researchexperimental studyexperimentsgraph attention networkgraph convolutional networkgraph neural networkimprovedin silicoinnovateinnovationinnovativeinsightknockout genemachine based learningmachine learning based frameworkmachine learning frameworkmultidimensional NMRmultidimensional nuclear magnetic resonancemultidimensional nuclear magnetic resonance techniquesnovelprogramsprotein functionresearch and developmentresolutionsresponsescreeningscreeningstemporal measurementtemporal resolutiontherapeutic agent developmenttherapeutic developmenttime measurementtool
Description preview
Abstract
Nuclear Magnetic Resonance (NMR) has emerged as an essential tool for providing atomic-level insights into
the structure, interactions, and dynamics of proteins, offering a unique perspective beyond what is achievable
with de novo structure prediction programs, revealing domain orientations, alternate conformations, allosteric
mechanisms,…
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