grant
Elucidation of the chemical and biological roles of five-carbon metabolism
Organization UNIVERSITY OF TENNESSEE KNOXVILLELocation KNOXVILLE, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20253,5-dihydroxy-3-methyl-pentanoic acidAD dementiaAddison disease-cerebral sclerosis syndromeAddison disease-spastic paraplegia syndromeAddison-Schilder syndromeAddressAdrenoleukodystrophyAeroseb-HCAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAndrogenic AgentsAndrogenic CompoundsAndrogensAutoregulationB subtilisB. subtilisBacillus subtilisBiologicalBiological FunctionBiological ProcessBiologyBronze Schilder diseaseCancer cell lineCancersCarbonCardiovascular DiseasesCell BodyCell FunctionCell PhysiologyCell ProcessCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessCetacortChemicalsCholesterolCoenzyme QCort-DomeCortefCortenemaCortisolCortisprayCortrilCystic FibrosisCytoplasmic MembraneDermacortDevelopmentDiphosphatesDiseaseDisorderDolicholEldecortEnzyme AntagonistEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEstrogensFanconi-Prader syndromeGGDPGGPP cpdGeneticGlycoproteinsGoalsGram-Positive BacteriaHealthHigh Throughput AssayHomeostasisHumanHuman ActivitiesHydrocortisoneHydrocortoneHytoneIntermediary MetabolismInvestigationIsomeraseIsomerase GeneIsomerismMalignant NeoplasmsMalignant TumorMetabolicMetabolic ProcessesMetabolismMevalonic AcidMissionMitochondriaModelingModern ManMucoviscidosisNAFLDNational Institutes of HealthNutracortOrganismPathway interactionsPhosphatesPhysiological HomeostasisPlasma MembranePrimary Senile Degenerative DementiaProctocortProductionPublic HealthPyrophosphatesResearchResearch MethodologyResearch MethodsResearch SupportRoleSchilder-Addison ComplexSiemerling-Creutzfeldt diseaseSiemerling-Creutzfeldt syndromeSubcellular ProcessTherapeutic AndrogenTherapeutic EstrogenTherapeutic InterventionTherapeutic Steroid HormoneUbiquinoneUnited States National Institutes of HealthX-Linked Adrenoleukodystrophyadrenocortical atrophy-cerebral sclerosis syndromeadrenoleukomyeloneuropathyadvanced analyticsanalogbiologiccardiovascular disorderdevelopmentalexperimentexperimental researchexperimental studyexperimentsfarnesyl diphosphatefarnesyl pyrophosphatefarnesylpyrophosphategeranylgeraniol diphosphategeranylgeranyl pyrophosphatehigh throughput screeninghormonal signalshormone signalsinhibitorinorganic phosphateintervention therapyisomerisopentenyl diphosphateisopentenyl pyrophosphateisoprenoidliving systemmalignancymelanodermic leukodystrophymitochondrialneoplasm/cancernext generationnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenovelpathwayplasmalemmaprenylationprimary degenerative dementiaresearch and methodssenile dementia of the Alzheimer typesocial rolesteroid hormonetherapeutic targettool
Description preview
Project Summary
Our long-term goal is to decipher the multifaceted role of five-carbon (C5) metabolism in cellular physiology and
disease. Five-carbon metabolism derives from the central hub of the isoprenoid pathway, which is necessary for
an array of critical bioactivities, including cell membrane integrity (e.g., cholesterol), glycoprotein…
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