grant
Elucidating the Signaling Landscapes Underlying Cellular and Regional Specification During Human Brain Development
NIHUS FederalResearch GrantFY20253-D print3-D printer3D Print3D cell culture3D culture3D printer3D printingATRAAddressAffectAreaAtlasesBar CodesBiochemistryBiological ChemistryBiomechanicsBiosensorBody TissuesBone Morphogenetic Protein GeneBone Morphogenetic ProteinsBone-Derived Transforming Growth FactorBrainBrain Nervous SystemBrain regionCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCallithrixCancersCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineCell SignalingCellLineCellsCellular MechanotransductionClustered Regularly Interspaced Short Palindromic RepeatsComplexCoupledDNADNA Synthesis FactorDNA seqDNA sequencingDNAseqDeoxyribonucleic AcidDevelopmentDevelopmental BiologyDevicesDiseaseDisorderEncephalonEndothelial Cell Growth FactorEngineeringExpression SignatureFGFFGF8FGF8 geneFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorGene Expression ProfileGeneticGenomeGenomicsGoalsHBGF-8HapaleHealthHistoryHumanImageIndividualIntracellular Communication and SignalingLigandsMalignant NeoplasmsMalignant TumorMarmosetsMechanical Signal TransductionMechanosensory TransductionMediatingMemoryMilk Growth FactorModelingModern ManMolecularMorphogenesisNeural Stem CellNeurodevelopmental DisorderNeurological Development DisorderOpticsOrganogenesisOrganoidsPathway interactionsPharmacologyPhysiologicPhysiologicalPlatelet Transforming Growth FactorPrimatesPrimates MammalsProcessProgenitor CellsProtocolProtocols documentationRecording of previous eventsResearchResolutionRetinoic AcidRoleRunningSHHSHH geneShort-Tusked MarmosetSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSonic HedgehogSpecific qualifier valueSpecificitySpecifiedStrains Cell LinesStratificationStructureSystemTGF BTGF-betaTGF-βTGFbetaTGFβTechniquesTherapeutic EffectTimeTissue EngineeringTissuesTrans Vitamin A AcidTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransmissionTretinoinTretinoinumVitamin A Acidall-trans-Retinoic Acidall-trans-Vitamin A acidanalytical toolbarcodebioengineered tissuebiological sensorbiological signal transductionbiomechanicalbone morphogenic proteincell fate specificationcell typecellular differentiationclustered regularly interspaced short palindromic repeats screencongenital brain disordercultured cell linedeep learningdeep learning methoddeep learning strategydesigndesigningdevelopmentaldevelopmental geneticsdevelopmental neurobiologydifferentiation factorsengineered tissuefetalgene expression patterngene expression signaturehiPSChigh dimensional datahistorieshuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimaginginduced human pluripotent stem cellsinsightinterdisciplinary approachmalignancymechanosensingmechanotransductionmorphogenetic processmorphogenic factorsmorphogensmultidimensional datamultidimensional datasetsmultidisciplinary approachneoplasm/cancernerve stem cellneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnotchnotch proteinnotch receptorsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopticalpathwayprime editingprogenitorprogenitor and neural stem cellsprogramsrecruitresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalstem cell organoidsstem cell-derived organoidsstem cellssynthetic biologytemporal measurementtemporal resolutionthree dimensional cell culturethree dimensional printingtime measurementtissue repairtissue-level behaviortooltrans-Retinoic Acidtranscriptional profiletranscriptional signaturetransmission process
Description preview
ABSTRACT
Assembly of the brain relies upon spatiotemporally coordinated action of a small number of intracellular
signaling pathways, which together govern an astonishingly wide array of processes, ranging from cell
differentiation to tissue morphogenesis. How a handful of pathways can provide the precision and specificity
required for the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click