grant
Elucidating the role of the hyaluronan on PGC development and ovarian reserve establishment
Organization MAGEE-WOMEN'S RES INST AND FOUNDATIONLocation Pittsburgh, UNITED STATESPosted 15 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years old4-methylumbelliferone7-hydroxy-4-methyl-coumarin7-hydroxy-4-methylcoumarinAcidsAdultAdult HumanAgeAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArchitectureAutoregulationBindingBody TissuesCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell ProtectionCell-Extracellular MatrixCellsCellular ProliferationCompanionsCytoplasmic DomainCytoplasmic TailCytoprotectionDeteriorationDevelopmentECMElementsEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEngineeringEngineering / ArchitectureEnvironmentExonsExtracellular MatrixFemaleGametesGenesGerm CellsGerm-Line CellsGlycosaminoglycansGoalsHAS2HAS2 geneHeterocephalusHomeostasisHumanHyaluronanHyaluronan Synthase 2HydrationHydration statusHydrogen OxideInflammatoryL-SerineLength of LifeLinkLongevityMaintenanceMammaliaMammalsMiceMice MammalsModelingModern ManMole RatsMolecular InteractionMolecular WeightMouse StrainsMucopolysaccharidesMurineMusOocytesOrganOutcomeOvarianOvarian agingOvaryOvocytesPerinatalPeripartumPhenotypePhysiological HomeostasisPlayPopulationPrimordial Germ CellProductionProgenitor CellsProliferatingPropertyProteinsPublicationsRegulationRejuvenationReproductive CellsReproductive PeriodsResearchRodentRodentiaRodents MammalsRoleScientific PublicationSeriesSerineSex CellSiteSomatic CellStem Cell likeStructure of primordial sex cellTestingTissuesUndifferentiatedWaterWomanadulthoodadvanced maternal ageadvanced reproductive ageagesaging human ovaryaging ovarycell typecytoprotectivedevelopmentaldrug developmentevidence baseextracellularfetalgranulosa cellhasA enzymehyaluronan synthasehyaluronan synthase 1hyaluronan synthetasehyaluronate synthasehyaluronate synthetasehyaluronic acid synthetasein uteroin vivoinhibitorinitial cellinnovateinnovationinnovativelife spanlifespanmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyovarian reserveovarian senescenceovulatory senescencepost-natal developmentpostnatalpostnatal developmentprematureprematurityprogenitor capacityprogenitor cell likeprogenitor cell proliferationprogenitor cell survivalprogenitor proliferationprogenitor survivalprogenitor-likepromoterpromotorreproductive agingreproductive cell senescencereproductive functionreproductive longevityreproductive senescenceself-renewself-renewalsexual cellsocial rolestem and progenitor cell proliferationstem cell characteristicsstem cell proliferationstem cell survivalstem cellsstem-likestemness♀
Description preview
ABSTRACT
In mammals generally, including humans, the ovary ceases its functions little more than halfway through a
female’s lifespan. This is strikingly different from the changes that occur in other organs, leading to a very long
post-reproductive period in humans. Female reproductive aging is characterized by a loss of follicles; follicles
are…
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