grant
Elucidating the role of genome organization in cDC1 development
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20263' Untranslated Regions3'UTR3-D3-Dimensional3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3DAffectAntigen PresentationAntigensArchitectureB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBiologyCCCTC-binding factorCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCTCF proteinCUT&RUNCancer TreatmentCas nuclease technologyCell BodyCell DifferentiationCell Differentiation processCellsChromatinChromatin LoopChromatin Loop DomainsCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexControl LocusCross PresentationDNA LoopDNA-binding protein CTCFDataDendritic CellsDevelopmentDevelopment PlansDifferentiated GeneDiseaseDisorderEdodekin AlfaElementsEngineeringEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExpression SignatureFamilyGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomeGoalsHealthHi-CHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHistonesIL-12IL12ImmuneImmunesImpairmentIn VitroInnate ImmunityInstitutionInterferon Type IInterleukin-12InvestigatorsKnowledgeLinkMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMediatingMentorsMiceMice MammalsMissionModelingMolecularMurineMusNIAIDNKSFNational Institute of Allergy and Infectious DiseaseNative ImmunityNatural ImmunityNatural Killer Cell Stimulatory FactorNon-Specific ImmunityNonspecific ImmunityNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesPatternPhasePhenotypePopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein ModificationRNA ExpressionRegulationRegulatory RegionsResearchResearch PersonnelResearchersResolutionRoleScientistSentinelSiteSourceSpecific qualifier valueSpecifiedSystemT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTreatment EfficacyVaccinesVeiled CellsWritingadaptive immune responseadaptive immunityanalyze gene expressionanti-cancer therapycancer therapycancer-directed therapycareer developmentcellular differentiationchromatin conformation capturechromatin remodelingchromosome capturechromosome conformation capturecohesincytokinedevelopmentalepigeneticallygene expression analysisgene expression assaygene expression patterngene expression signaturegenetic regulatory elementimmunogenin vivoinsightintervention efficacymouse modelmultiomicsmultiple omicsmurine modelnovelpanomicspathogenpostmitoticprogramsresolutionsresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqskillssocial rolesuccesstherapeutic efficacytherapy efficacythree dimensionalthymus derived lymphocytetooltranscription factortranscriptional profiletranscriptional profilingtranscriptional signature
Description preview
PROJECT SUMMARY/ABSTRACT
Dendritic cells are immune sentinels capable of sensing pathogen-derived products and initiating an adaptive
immune response. Type 1 conventional DCs (cDC1s) are a specialized subset of DCs that excel in cross-
presenting exogenous antigens to CD8+ T cells and secreting interleukin-12, making them an attractive target
in…
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