grant
Elucidating the role of cyclin G-associated kinase as a regulator of podocyte autophagy
NIHUS FederalResearch GrantFY202521+ years oldATP-protein phosphotransferaseActive Follow-upAddressAdultAdult HumanAffectAffinity ChromatographyAssayAutophagocytosisAutophagosomeAutoregulationBindingBioassayBiological AssayC-terminalCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClathrinCyclin G-Associated KinaseDataData BasesDatabasesDevelopmentDiagnosisDifferential Gene ExpressionDiseaseDisorderDown-RegulationDysfunctionEndocytic VesicleEndocytotic VesicleEpithelial CellsExhibitsFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Foot ProcessFoundationsFunctional disorderGAKGAK geneGEM modelGEMM modelGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGenesGenetic TranscriptionGenetically Engineered MouseGlomerular diseaseGoalsHomeostasisImageImmunoblottingImmunofluorescenceImmunofluorescence ImmunologicImpairmentIn VitroInjuryKO miceKidney FailureKidney InsufficiencyKinase Family GeneKinasesKnock-outKnock-out MiceKnockoutKnockout MiceLabelLearningLysosomesMaintenanceMeasuresMechanistic Target of RapamycinMediatingMentorshipMetabolicMiceMice MammalsMolecular InteractionMonitorMurineMusNatureNephrologyNull MousePaperPathway interactionsPatientsPedicelPersonsPhenotypePhosphotransferase GenePhosphotransferasesPhysiciansPhysiological HomeostasisPhysiopathologyPlayPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProliferatingProtein KinaseProtein ModificationProteinuriaPublishingQuantitative RTPCRQuantitative Reverse Transcriptase PCRRAFT1RNA ExpressionRenal CellRenal FailureRenal Glomerular Diseases and SyndromesRenal InsufficiencyRenal functionRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeResearchRibosomesRoleScientistSpecialized Epithelial CellStrains Cell LinesStructureSubcellular ProcessTechniquesTestingTherapeuticTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTransgenic OrganismsTranslatingTransphosphorylasesUpregulationVesicleVisceral Epithelial CellWestern BlottingWestern Immunoblottingactive followupadulthoodaffinity purificationanalyze gene expressionautophagycareercell damagecell injurycellular damagechronic kidney diseasecultured cell linedamage to cellsdata basedevelopmentalexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgene expression analysisgene expression assaygenetically engineered mouse modelgenetically engineered murine modelglomerular filtrationglomerular sclerosisglomerular visceral epithelial cellglomerulosclerosisglycogen synthase a kinasehydroxyalkyl protein kinaseimagingin vitro Assayin vivoinjuriesinjury to cellsinjury to tissueinsightkidney cellkidney functionknock-downknockdownmTORmammalian target of rapamycinmouse modelmurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoverexpressoverexpressionpathophysiologypathwayphosphorylase b kinase kinasepodocytepostmitoticpreventpreventingprotein blottingqRTPCRrepairrepairedsocial roletherapeutic biomarkertherapeutic markertherapeutic targettissue injurytranscriptional profilingtransgenic
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Project Summary:
An estimated 37 million people in the US and over 800 million people worldwide are affected by chronic kidney
disease (CKD), which is defined as persistent abnormalities in the structure and/or function of the kidneys.
Integral to the filtering function of the kidney are podocytes, which are highly specialized, post-mitotic…
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