grant

Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia

Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 20 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AD related dementiaADRDActivities of Daily LivingActivities of everyday lifeAddressAfter CareAfter-TreatmentAftercareAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmentiaAnticholinesterase AgentsAnticholinesterase DrugsAnticholinesterasesAttentionBackBrainBrain Nervous SystemBrain StemBrainstemCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell NucleusCharacteristicsCholinesterase InhibitorsClinicalClinical assessmentsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCohort StudiesConcurrent StudiesCortical DesynchronizationsCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDWI (diffusion weighted imaging)DWI-MRIDataDementiaDenervationDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisease Frequency SurveysDisturbance in cognitionDorsumDysfunctionEEGElectroencephalogramElectroencephalographyEncephalonEyeEyeballFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGaitGoalsHealth Care CostsHealth CostsHigh PrevalenceHourImpaired cognitionImpairmentIndividualIntervention StudiesInvestigationKnowledgeLB dementiaLB diseaseLB disorderLeadLewy Body DementiaLewy Body DiseaseLewy Body Type Senile DementiaLewy body disorderLewy dementiaLewy diseaseLewy disorderLinkLong-term cohort studyLongitudinal cohort studyMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMesencephalonMethodsMid-brainMidbrainMidbrain structureMonitorNMR ImagingNMR TomographyNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNuclear Magnetic Resonance ImagingNucleusOutcome MeasureParticipantPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPeriodicalsPhysiopathologyPostureQOLQuality of lifeQuestionnairesResearchRestRoleSymptomsSystemTestingThalamic structureThalamusTimeVisual HallucinationWakefulnessZeugmatographyalertnessawakebasal forebraincase-controlled studiescholinergiccognitive assessmentcognitive dysfunctioncognitive losscognitive testingcohortdMRIdaily living functiondaily living functionalitydevelop therapydevelopmentaldiffusion tensor imagingfMRIfunctional abilityfunctional capacityheavy metal Pbheavy metal leadimprovedimproved outcomeinnovateinnovationinnovativeinsightintervention developmentintervention researchinterventional researchinterventional studyinterventions researchmeasurable outcomemild cognitive disordermild cognitive impairmentmotor symptomnetwork dysfunctionneural controlneural regulationneurobehavioral symptomneuromodulationneuromodulatoryneuroregulationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoutcome measurementpathophysiologypatient oriented outcomesperiodicperiodicalpost interventionpost treatmentsocial rolethalamictherapeutic agent developmenttherapeutic developmenttherapy developmenttreatment developmentvigilance
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Cognitive fluctuations (CF) are a hallmark of Lewy body dementia (LBD), presenting as spontaneous, unpredictable episodes of reduced attention and alertness. In addition to being common, CF in LBD are associated with greater impairment in activities of daily living, worse quality of life, and greater healthcare costs. Despite their high prevalence…

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Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia — VIRGINIA COMMONWEALTH | Dev Procure