grant
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 20 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AD and related dementiaAD related dementiaADRDActivities of Daily LivingActivities of everyday lifeAddressAfter CareAfter-TreatmentAftercareAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmentiaAnticholinesterase AgentsAnticholinesterase DrugsAnticholinesterasesAttentionBackBrainBrain Nervous SystemBrain StemBrainstemCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell NucleusCharacteristicsCholinesterase InhibitorsClinicalClinical assessmentsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCohort StudiesCortical DesynchronizationsCross-Sectional StudiesCross-Sectional SurveyDWI (diffusion weighted imaging)DWI-MRIDataDementiaDenervationDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisease Frequency SurveysDisturbance in cognitionDorsumDysfunctionEEGElectroencephalogramElectroencephalographyEncephalonEyeEyeballFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGaitGoalsHealth Care CostsHealth CostsHigh PrevalenceHourImpaired cognitionImpairmentIndividualIntervention StudiesInvestigationKnowledgeLB dementiaLB diseaseLB disorderLeadLewy Body DementiaLewy Body DiseaseLewy Body Type Senile DementiaLewy Body spectrum diseasesLewy Body spectrum disordersLewy body disorderLewy dementiaLewy diseaseLewy disorderLinkLong-term cohort studyLongitudinal cohort studyMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMesencephalonMethodsMid-brainMidbrainMidbrain structureMonitorNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingNucleusOutcome MeasureParticipantPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPeriodicalsPhysiopathologyPostureQOLQuality of lifeQuestionnairesResearchRestRoleSymptomsSystemTestingThalamic structureThalamusTimeVisual HallucinationWakefulnessZeugmatographyalertnessawakebasal forebraincase-control surveycase-controlled studiescholinergiccognitive assessmentcognitive dysfunctioncognitive losscognitive testingcohortcohort research studycohort surveycross-sectional research studydMRIdaily living functiondaily living functionalitydevelop therapydevelopmentaldiffusion tensor imagingfMRIfunctional abilityfunctional capacityheavy metal Pbheavy metal leadimprovedimproved outcomeinnovateinnovationinnovativeinsightintervention developmentintervention researchinterventional researchinterventional studyinterventions researchmeasurable outcomemild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmotor symptomnetwork dysfunctionneural controlneural regulationneuromodulationneuromodulatoryneuroregulationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoutcome measurementpathophysiologypatient oriented outcomesperiodicperiodicalpost interventionpost treatmentsocial rolethalamictherapeutic agent developmenttherapeutic developmenttherapy developmenttreatment developmentvigilance
Description preview
Cognitive fluctuations (CF) are a hallmark of Lewy body dementia (LBD), presenting as spontaneous, unpredictable episodes of reduced attention and alertness. In addition to being common, CF in LBD are associated with greater impairment in activities of daily living, worse quality of life, and greater healthcare costs. Despite their high prevalence…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click