grant
Elucidating the Molecular Determinants of Functional Specificity in Intrinsically Disordered Proteins
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 5 Apr 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AddressAutomobile DrivingBehaviorBehavior ControlBehavioral ManipulationBindingBiologic ModelsBiologicalBiological FunctionBiological ModelsBiological ProcessC-terminalCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsComplexDevelopmentDiseaseDisorderEnvironmentFamilyGene TranscriptionGenetic TranscriptionGoalsHealthHumanIntracellular Communication and SignalingLinkModel SystemModelingModern ManMolecularMolecular InteractionOutcomePlayProtein ConformationProteinsRNA ExpressionRegulationResearchRoleSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureSubcellular ProcessSystemTherapeuticTranscriptionTranscriptional ControlTranscriptional Regulationbehavioral controlbiologicbiological signal transductiondesigndesigningdevelopmentaldrivingdynamic systemdynamical systemflexibilityflexiblehuman diseaseinsightpolypeptideprogramsprotein protein interactionresponsesocial role
Description preview
PROJECT SUMMARY
Intrinsically disordered proteins, or IDPs, have numerous essential roles in cellular signaling and regulation. In
many ways, IDPs are ideally suited for carrying out important regulatory roles in complex environments. IDPs do
not adopt a single stable structure in isolation, are highly dynamic, and can engage multiple binding…
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