grant
Elucidating the impact of immune imprinting on SARS-CoV-2 variant vaccination strategies using a humanized mouse model
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike protein2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody RepertoireAntibody ResponseAntibody titer measurementAntigen VariationAntigenic DeterminantsAntigenic VariabilityAntigenic VariationAntigensAssayB blood cellsB cellB cell repertoireB cellsB-CellsB-LymphocytesB-cellB.1.1.529B.1.617.2BNT 162b2BNT162b2BindingBinding DeterminantsBioassayBioinformaticsBiological AssayBiomedical ResearchBlood SerumCOVID-19 S proteinCOVID-19 antigenCOVID-19 immunityCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 vaccinationCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID19 virusCessation of lifeClinical Treatment MoabCoV-2CoV2Communicable DiseasesCryo-electron MicroscopyCryoelectron MicroscopyDataDeathDelta variantDevelopmentDoctor of PhilosophyDoseEffectivenessElectron CryomicroscopyEnvironmentEpidemicEpitopesEvolutionExposure toFutureGenesGerm LinesGoalsHumanHumoral ImmunitiesIGHIGH@ gene clusterIg Somatic HypermutationIgH locusImmuneImmune EvasionImmune GlobulinsImmune responseImmune systemImmunesImmunizationImmunizeImmunochemical ImmunologicImmunoglobulin Heavy Chain GenesImmunoglobulin Heavy GeneImmunoglobulin Heavy LocusImmunoglobulin Somatic HypermutationImmunoglobulinsImmunologicImmunologicalImmunologicallyImmunologicsImmunologyInfectionInfectious DiseasesInfectious DisorderInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AJunior PhysicianKnowledgeLaboratoriesLengthLightMAb TherapeuticsMedical centerMedicineMemory B CellMemory B-LymphocyteMentorsMessenger RNAMiceMice MammalsMicrobiologyModern ManMolecularMolecular InteractionMonoclonal AntibodiesMurineMusOmicron variantOrthomyxovirus Type APatient CarePatient Care DeliveryPatternPfizer covid19 vaccinePfizer-BioNTech COVID-19 vaccinePfizer-BioNTech coronavirus disease 2019 vaccinePfizer/BioNTech vaccinePh.D.PhDPhotoradiationPhysiciansPlacebosPlayPositionPositioning AttributePost-vaccination infectionProductionProteinsPublic HealthRNA immunizationRNA vaccinationRNA vaccineRNA-based vaccineResearchRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 B.1.1.529SARS-CoV-2 B.1.617.2SARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 antigenSARS-CoV-2 deltaSARS-CoV-2 immunitySARS-CoV-2 omicronSARS-CoV-2 omicron variantSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSARS-CoV-2 vaccinationSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SarbecovirusScientistSerumSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 immunitySevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome coronavirus 2 vaccinationSevere acute respiratory syndrome related corona virus 2Sham TreatmentSingle cell seqSortingSpinal ColumnSpineSplenocyteStructureSurface Plasmon ResonanceTechniquesTestingTherapeuticTherapeutic Monoclonal AntibodiesTrainingTransfectionType A InfluenzaUniversitiesUpdateVSVVaccinatedVaccinationVaccine DesignVaccineeVaccinesVariantVariationVertebral columnVesicular Stomatitis VirusVesicular stomatitis Indiana virusViralVirusWorkWuhan coronavirusantibody titeringantibody-based immunitybackbonebooster dosebooster shotbooster vaccinebreakthrough infectioncare for patientscare of patientscareercaring for patientscoronavirus disease 2019 S proteincoronavirus disease 2019 antigencoronavirus disease 2019 immunitycoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 vaccinationcoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease-19 viruscross immunitycross protectioncross reactivitycryo-EMcryoEMcryogenic electron microscopydevelopmentalenvironment enrichmentenvironment enrichment for laboratory animalsenvironmental enrichmentenvironmental enrichment for laboratory animalshCoV19host responsehumanized micehumanized mouseimmune evasiveimmune system responseimmunity against COVID-19immunity against SARS-CoV-2immunity against Severe acute respiratory syndrome coronavirus 2immunity against coronavirus disease 2019immunity to COVID-19immunity to SARS-CoV-2immunity to Severe acute respiratory syndrome coronavirus 2immunity to coronavirus disease 2019immunization strategyimmunogenimmunogenicityimmunoglobulin heavy chain locusimmunoresponseimprintimprovedinnovateinnovationinnovativeinsightmAbsmRNAmRNA immunizationmRNA vaccinationmRNA vaccinemRNA-based vaccinemodel of animalmonoclonal Absmonoclonal antibody drugsmouse modelmultidisciplinarymurine modelnCoV2neutralizing antibodynew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnext generation therapeuticsnext generation vaccinesnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapynovel vaccinesomicron variant of COVID-19omicron variant of SARS-CoV-2pathogenreceptor bindingreceptor boundresponsesevere acute respiratory syndrome coronavirus 2 B.1.1.529severe acute respiratory syndrome coronavirus 2 B.1.617.2severe acute respiratory syndrome coronavirus 2 antigensevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssham therapysingle cell next generation sequencingsingle cell sequencingsocial rolesomatic hypermutationspike proteins on SARS-CoV-2structural biologytherapeutic mAbsvaccinate against COVID-19vaccinate against SARS-CoV-2vaccinate against coronavirus disease 2019vaccinate against severe acute respiratory syndrome coronavirus 2vaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination against COVID-19vaccination against SARS-CoV-2vaccination against Severe acute respiratory syndrome coronavirus 2vaccination against coronavirus disease 2019vaccination strategyvaccine boostvaccine strategyvirology
Description preview
PROJECT SUMMARY / ABSTRACT: Rationale: Continued evolution of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) has led to immune-evasive variants that pose a persistent threat to global public
health. Updated vaccines are needed to provide improved immune responses against emerging variants, but
current approaches targeting the Omicron…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click