grant
Elucidating the biological mechanisms underlying the association between EBV and MS in African Americans
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 15 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY2025AddressAffectAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAntibodiesAntibody ResponseAntibody titer measurementAntigenic DeterminantsAntigensArmed Forces PersonnelAssayAustriaAutoantibodiesAutoantigensAutoimmuneAutologous AntigensBinding DeterminantsBioassayBiologicalBiological AssayBiological MarkersBlack PopulationsBlack groupBlack individualBlack peopleBlacksBloodBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenBurkitt HerpesvirusBurkitt Lymphoma VirusCMVChronicClinicalClinical DataCollaborationsCollectionComplicationCross ReactionsCrystallinsCytomegalovirusDataData BasesDatabasesDiagnosisDiagnosticDifferences between sexesDiffers between sexesDisablingDiseaseDisorderDisseminated SclerosisEB virusEBVEBV InfectionsEarly identificationEarly treatmentEpitopesEpstein Barr VirusEpstein-Barr Virus InfectionsEpstein-Barr viral infectionsEuropean ancestryFinlandFundingFutureGenetic DeterminismGlycoproteinsHCMVHHV-4HHV4High PrevalenceHumanHuman Herpesvirus 4Humoral ImmunitiesImmune responseImmunologyIncidenceIndividualInfectionInfectious Mononucleosis VirusInvestigationInvestigatorsLaboratoriesLightLongitudinal StudiesMS treatmentMeasurementMedical RecordsMetabolic GlycosylationMilitaryMilitary PersonnelModern ManMolecular MimicryMorbidityMorbidity - disease rateMultiple SclerosisNINDSNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve DegenerationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeuron DegenerationNucleic AcidsOnset of illnessPathogenesisPathogenicityPeptidesPersonsPhosphorylationPhotoradiationPopulationPredicting RiskPreventative interventionPreventionProgressive DiseaseProtein ArrayProtein PhosphorylationProteomeRaceRacesReaction TimeResearchResearch PersonnelResearchersResponse RTResponse TimeRiskRoleSalivary Gland VirusesSamplingSelf-AntigensSerologySerumSex DifferencesSexual differencesSourceSwedenSymptomsTimeTrainingTranscendVIT DVaccinesViralViral AntibodiesViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirusVirus DiseasesVitamin DWomanactive dutyactive serviceadult youthagesanti-viral antibodyantibody titeringantibody-based immunityautoimmune antibodyautoreactive antibodybio-markersbiobankbiologicbiologic markerbiomarkerbiorepositoryblack femaleblack maleblack manblack menblack womenco-infectioncoinfectioncostcross reactivitycytomegalovirus groupdata basedecrease disabilitydecrease in disabilitydevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisability reductiondisease onsetdisorder onsetearly therapyexpectationexperienceforecasting riskgenetic determinantglycosylationhost responsehuman viromeimmune system responseimmunogenimmunoresponseinsightinsular sclerosisinterestintervention for preventionlens proteinlessen disabilitylong-term studylongitudinal outcome studiesmachine learning based methodmachine learning methodmachine learning methodologiesmembermenmilitary populationminimize disabilitymitigate disabilitymultiple sclerosis therapymultiple sclerosis treatmentneural degenerationneurodegenerationneurodegenerativeneurofilamentneurological degenerationneurological diseaseneuronal degenerationnovelpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredictive signaturepredicts riskpreventpreventingprevention interventionpreventional intervention strategypreventive interventionprospectiveprotective factorspsychomotor reaction timeracialracial backgroundracial originreduction in disabilityrisk predictionrisk predictionsscreeningscreeningsself reactive antibodysexsex based differencessex-dependent differencessex-related differencessex-specific differencesslow disabilitysocial rolevaccine developmentviral infectionvirus infectionvirus proteinvirus-induced diseaseyoung adultyoung adult ageyoung adulthoodyoung manyoung menyoung womanyounger age
Description preview
PROJECT SUMMARY: Despite progress in treatment, multiple sclerosis (MS) continues to be a chronic
progressive disease with a high personal and societal impact, and its incidence has been increasing over the
past few decades, particularly in women and in African Americans. The recent discovery that the Epstein-Barr
virus (EBV) is the leading cause…
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