grant
Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 6 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025Amino AcidsAminoacetic AcidAssayBioassayBiologic ModelsBiological AssayBiological ModelsBiologyBreastCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer PatientCancersCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell CycleCell Cycle ArrestCell Division CycleCell SignalingCell surfaceCellsChargeCodonCodon NucleotidesComplexCyclin-Dependent KinasesCyclin-Dependent Protein KinasesDNA mutationDietDiseaseDisorderEnvironmentEnzyme GeneEnzymesGene TranscriptionGeneralized GrowthGenesGenetic ChangeGenetic DiseasesGenetic TranscriptionGenetic defectGenetic mutationGlycineGrowthHealthHistocompatibility ComplexHistocompatibility ComplicesHumanHuman GeneticsHypoxiaHypoxicImmuneImmunesImmunoblottingImmunocompetentImmunofluorescenceImmunofluorescence ImmunologicImpairmentInitiation CodonInitiator CodonIntellectual disabilityIntellectual functioning disabilityIntellectual limitationInterventionIntracellular Communication and SignalingKPC genetically-engineered mouseKPC modelKPC mouseKPC murineL-SerineLSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-CreLSL-KrasG12D/+;LSL-p53R172H/+;Pdx-1-CreMajor Histocompatibility ComplexMajor Histocompatibility Complex GeneMajor Histocompatibility ComplicesMalignant MelanomaMalignant NeoplasmsMalignant TumorMeasuresMelanomaMiceMice MammalsModel SystemModern ManMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMurineMusMutationNerveNerve Growth FactorsNeuronotrophic FactorsNeurotrophic ProteinsNuclearNutrientNutrient DepletionOncogenesisOxygen DeficiencyPancreas Ductal AdenocarcinomaPancreatic Ductal AdenocarcinomaPancreatic ductPathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPerceptionPerfusionPhosphorylationPre-tRNAProcessProductionPrognosisProtein BiosynthesisProtein PhosphorylationProteinsProteomeProteomicsRNA ExpressionRNA, Transfer, PrecursorsRegulationRegulatory PathwayReporterResearchResistanceRibo-seqRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSer-tRNASerineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpatial DistributionStart CodonStarvationTherapeuticThymotaxinTissue GrowthTranscriptionTransfer RNATranslation InitiationTriplet Codon-Amino Acid AdaptorTumor BurdenTumor LoadWestern BlottingWestern ImmunoblottingWirsung canalWorkaminoacidbeta-2 Microglobulinbiochemical modelbiological signal transductioncdk Proteinsclustered regularly interspaced short palindromic repeats screendeprivationdietarydietary restrictiondietsentire genomefull genomegenetic conditiongenetic disordergenome mutationhypoimmunityimmune competentimmune deficiencyimmunodeficiencyimproved outcomeinnervationinsightintellectual and developmental disabilitylimited intellectual functioningmRNA Translationmalignancymolecular modelingmouse modelmurine modelmutantneoplasm/cancernerve supplynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachontogenypancreatic carcinogenesispancreatic oncogenesispancreatic tumorigenesispathwaypatient oriented outcomespreferencepreventpreventingprotein blottingprotein synthesisresistantresponserestricted dietribosome footprint profilingribosome profilingserine-tRNAseryl-tRNAsocial roletRNAtRNA PrecursortRNA, serine(UCX)-transfer Ribonucleic acidstumortumor ablationtumorigenesiswhole genomeβ2 Microglobulin
Description preview
Pancreatic ductal adenocarincomas (PDAC) is an aggressive disease with poor prognosis and is
characterized by a unique microenvironment that is severely depleted of amino acids (AAs). Dietary AA
interventions, such as serine/glycine (Ser/Gly)-free diet, can reduce PDAC tumor burden. However, PDAC cells
can regulate various pathways to adapt, grow…
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