grant
Elucidating mechanisms of spermatogonial stem cell competition
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Jan 2025Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AdhesionsAllelesAllelomorphsAssayBasal Transcription FactorBasal transcription factor genesBinding ProteinsBioassayBiological AssayCell BodyCell-Extracellular MatrixCellsChromatinDisadvantagedDiseaseDisorderDrosophilaDrosophila genusECMExtracellular MatrixExtracellular Matrix ProteinsFathersFosteringGametesGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGerm CellsGerm-Line CellsGoalsHumanImmunofluorescenceImmunofluorescence ImmunologicLabelLawsLigand Binding ProteinLigand Binding Protein GeneModelingModern ManMolecularPaternal AgePost-Transcriptional Gene SilencingProtein BindingProteinsPublishingRNA InterferenceRNA SilencingRNA-Binding ProteinsRNAiRepressionReproductive CellsResearchRoleSequence-Specific Posttranscriptional Gene SilencingSex CellSperm stem cellTesticlesTestingTestisTranscription Factor Proto-OncogeneTranscription factor genesTransmissionTumor CellWorkZNFsZn-finger nucleaseadult progenitoradult stem cellage associated effectsage effectage related effectsaging effectbound proteincofactordesigndesigningfruit flygerm stem cellsgermline progenitorgermline progenitor cellsgermline stem cellshistone H3 methyltransferasehistone methylasehistone methyltransferaseimpact of ageinfluence of ageinitial cellinnovateinnovationinnovativeknowledge baselive cell imagelive cell imaginglive cellular imagelive cellular imagingmutantneoplastic cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoffspringperlecanprogenitor cell divisionprogenitor cell poolprogenitor cell populationprogenitor cell renewalprogenitor divisionprogenitor poolprogenitor populationprogenitor renewalprotein expressionrecruitsegregationsexual cellsocial rolesomatic progenitorsomatic stem cellsperm progenitorspermatogonia cellspermatogonia progenitorspermatogonia stem cellsspermatogonial cellspermatogonial progenitorspermatogonial stem cellsstem and progenitor cell divisionstem and progenitor cell populationstem and progenitor cell renewalstem cell divisionstem cell poolstem cell populationstem cell renewalstem cells in the germlinetranscription factortranscriptomicstransmission processzinc finger nucleasezinc finger nucleases
Description preview
Project Summary
The broad, long-term objectives of this application are to characterize mechanisms that allow a competitive
germline stem cell (GSC) and its descendants to dominate the GSC population and cause super-Mendelian
inheritance. The proposal will determine how a GSC in the Drosophila testis remodels its niche and causes the
selective…
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