grant
Elucidating learning-induced molecular signatures in hippocampal mature oligodendrocytes at single-cell and spatial resolution: Implications for hippocampal function
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 5 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AffectAmmon HornApplications GrantsAssayBehaviorBehavioralBioassayBiological AssayCNS plasticityCalciumCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCharacteristicsChromatinCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCornu AmmonisCoupledD-GlucoseDataDegenerative Neurologic DisordersDevelopmentDextroseDisturbance in cognitionDorsalDysfunctionExhibitsExploratory/Developmental GrantExpression SignatureFiberFoundationsFunctional disorderFutureGene ExpressionGene Expression ProfileGenesGlucoseGrant ProposalsHarvestHeterogeneityHippocampusHourImpaired cognitionIn SituIntracellular Communication and SignalingInvestigationLabelLearningLinkMemoryMetabolicMolecularMolecular FingerprintingMolecular ProfilingMyelinNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologic Degenerative ConditionsNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuronal PlasticityNeuronsNucleusOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomePatternPhotometryPhysiopathologyProcessProtein-Serine KinaseProtein-Serine-Threonine KinasesProtein-Threonine KinaseR21 MechanismR21 ProgramRegulationReportingResearchResolutionRoleSerine KinaseSerine-Threonine KinasesSerine/Threonine Protein Kinase GeneSignal TransductionSignal Transduction SystemsSignalingTechniquesTestingTherapeutic InterventionThreonine KinaseTrainingTranscriptTransgenic MiceUpregulationViralWorkbiological signal transductioncandidate selectioncell typecentral nervous system plasticitycognitive defectscognitive dysfunctioncognitive losscognitive processdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldifferential expressiondifferentially expressedenergy efficiencyepigenomicsexperienceexperimentexperimental researchexperimental studyexperimentsexploratory developmental studygene expression patterngene expression signaturegene manipulationgenetic manipulationgenetically manipulategenetically perturbhippocampalhippocampal subregionsin vivoin vivo Modelinsightintervention therapylong-term memorymemory consolidationmolecular profilemolecular signaturemultiomicsmultiple omicsmyelinationneural plasticityneurodegenerative illnessneurodevelopmental diseaseneurological diseaseneuronalneuronal circuitneuronal circuitryneurophysiologicalneurophysiologyneuroplasticneuroplasticityneuropsychiatric diseaseneuropsychiatric disordernew approachesnovelnovel approachesnovel strategiesnovel strategypanomicspathophysiologyprogramsresolutionsresponsescRNA sequencingscRNA-seqsegregationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial memorysubstantia albatherapeutic targettranscriptional differencestranscriptional profiletranscriptional signaturetranscriptome profilingtranscriptomic profilingtranscriptomicswhite matter
Description preview
Project Summary/Abstract
Neuronal plasticity is fundamental for cognitive and behavioral processes. Emerging evidence has shed light on
the role of oligodendrocytes in regulating activity-dependent plasticity. Although primarily recognized for their role
in forming myelin, mature oligodendrocytes also perform additional metabolic functions that…
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