grant
Elucidating how environmental perturbations determine the duration of enteric viral infection
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AbscissionAffectAnimal Experimental UseAnimal ExperimentationAnimal HusbandryAnimal ModelAnimal Models and Related StudiesAnimal ResearchAnti-viral AgentsAntigensAssayAstrovirusBehaviorBindingBioassayBiological AssayBody BuildBody TypesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell Communication and SignalingCell SignalingCellsChronicCorticosteroneDNA mutationDataDevelopmentDropsEnteralEntericEnvironmentEnvironmental FactorEnvironmental Risk FactorEpithelial CellsExcisionExtirpationGastroenteritisGastrointestinal DiseasesGenesGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGlucocorticoid ReceptorGlucocorticoidsGoblet CellsHumanHuman BiologyIFNImmuneImmune EvasionImmune reactionImmune responseImmune systemImmunesImmunityImmunocompetentIn VitroIndividualInfectionInterferonsInterventionIntervention StrategiesIntestinalIntestinesIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLong-term infectionMediatingMiceMice MammalsModelingModern ManMolecular InteractionMucous body substanceMucusMurineMusMutationNull MouseOralOrganoidsOutcomePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePopulationProceduresProteinsRNA VirusesReactionReceptor SignalingRecoveryRemovalReportingReproducibilityResolutionRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderRoleShapesSignal TransductionSignal Transduction SystemsSignalingSomatotypeStressSurgical RemovalSymptomsSystemT cell responseT-Cell ActivationT8 CellsT8 LymphocytesTechniquesTeff cellTestingTimeTransmissionTropismValidationViralViral BurdenViral DiseasesViral GenomeViral LoadViral Load resultVirusVirus Diseasesactivate T cellsacute infectionadaptive immunityanimal experimentationsanimal facilityanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbiological adaptation to stressbiological signal transductionbowelcell typechronic infectiondesigndesigningdevelopmentaldiarrheal diseasediarrheal illnesseffector T cellenteral infectionenteric infectionenteric pathogen infectionenteric viral infectionenteric virus infectionenteropathogen infectionenteropathogenic infectionenvironmental riskexperimentexperimental researchexperimental studyexperimentsgastrointestinal disordergastrointestinal symptomgenome mutationhost responseimmune competentimmune evasiveimmune system responseimmunogenimmunoreactionimmunoresponseimprovedin vivoinfected with enteropathogenintestinal epitheliumintestinal infectionintestine infectionmodel of animalmucousnovelpersistent infectionpharmaceuticalpreventpreventingreaction; crisisresectionresolutionssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstress hormonestress induced hormonestress related hormonestress responsestress; reactiontransmission processvalidationsviral detectionviral infectionvirus detectionvirus genomevirus infectionvirus-induced disease
Description preview
SUMMARY
For many non-integrating RNA viruses, a typical course of infection involves a brief period of peak viral
burden followed by rapid resolution. However, the virus or viral products are detected in a subset of individuals
for a prolonged period for a growing list of viruses previously considered non-persistent. Prolonged infection may…
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