grant
Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 8 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AAV vectorAAV-based vectorAIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActivities of Daily LivingActivities of everyday lifeAdvanced DevelopmentAmino Acid SequenceAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody ResponseAntigen-Presenting CellsAssociated VirusesAutomobile DrivingBiodistributionBody TissuesCITE sequencingCITE-seqCITEseqCapsidCell BodyCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCellular TropismClinical ResearchClinical StudyClinical TrialsDataDevelopmentDirected Molecular EvolutionDisease remissionDoctor of PhilosophyDoseDrugsElementsEngineeringEngraftmentExhibitsFutureGene ExpressionGene TranscriptionGene TransferGenetic TranscriptionGrantHIVHIV AntibodiesHIV InfectionsHIV PreventionHIV cureHIV functional cureHIV interventionHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV virus infectionHIV-1 cureHIV-1 functional cureHIV-1 infectionHIV-1 interventionHIV-1 preventionHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHIV-Associated AntibodiesHIV/AIDS cureHIV/AIDS preventionHTLV-III AntibodiesHTLV-III-LAV AntibodiesHumanHuman Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesImmuneImmune responseImmune signalingImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologic StimulationImmunologicalImmunological StimulationImmunologicallyImmunologicsImmunologyImmunostimulationIndividualInfection by HIV-1Infection from HIV-1Infection of HIV-1IntramuscularIntramuscular InjectionsKO miceKnock-out MiceKnockout MiceLAV AntibodiesLAV-HTLV-IIILibrariesLinkLymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusMacacaMacaqueMeasuresMediatingMedicationMiceMice MammalsModern ManMurineMusMuscleMuscle TissueNHP modelsNull MouseOutcomeParticipantPatientsPatternPh.D.PhDPharmaceutical PreparationsPhasePhase I StudyPrevent HIVPrimary Protein StructurePrincipal InvestigatorRNA ExpressionReceptor ProteinRemissionResearchResolutionRoleSHIVSafetySatellite VirusesSerotypingSignal PathwayTestingTissuesTranscriptionTransgenesTropismViralVirusVirus-HIVWorkaccessory celladeno-associated viral vectoradeno-associated virus vectorcell transductioncellular indexing of transcriptomes and epitopes by single cell sequencingcellular transductioncytokinedaily living functiondaily living functionalitydesigndesigningdevelopmentaldirected evolutiondrivingdrug/agentengineered immune systemexperimentexperimental researchexperimental studyexperimentsfunctional abilityfunctional capacityhost responsehuman immunodeficiency virus curehuman immunodeficiency virus infectionhuman subjecthumanized micehumanized mouseimmune engineeringimmune system responseimmunoengineeringimmunogenicityimmunoprophylaxisimmunoresponseimprovedin vivoin vivo Modelinfected with HIVinfected with human immunodeficiency virusintramuscular drug administrationmedical collegemedical schoolsmodel of animalmulti-modalitymultimodalitymuscularneutralizing antibodynext generationnon-human primatenonhuman primatenonhuman primate modelsnovelparticipant enrollmentpatient enrollmentphase 1 studyprevent AIDSprevent human immunodeficiency virusprofessorprogramsprotein sequencereceptorresolutionsscRNA sequencingscRNA-seqschool of medicinesimian HIVsimian human immunodeficiency virussingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletransduced cellstransduction efficiencytransgenetransgene expressiontreat HIVtreat Human Immunodeficiency Virusvector
Description preview
Project Summary / Abstract
This proposal describes the framework of an R01 grant for Alejandro Balazs, PhD. Dr. Balazs is
currently an assistant professor at Harvard Medical School working as a principal investigator at the Ragon
Institute of MGH, MIT & Harvard. Dr. Balazs’ research is focused on engineering the immune system via gene
transfer as…
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