grant
Electrochemical Fluorination for Organic Synthesis
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AddressAffectBinding SitesBiologicalBiologyChargeChemicalsChemistryCombining SiteCouplingDerivationDerivation procedureDevelopmentDrug KineticsDrugsElectrochemistryElectrodesElectronicsElectronsEnzyme GeneEnzymesFDA approvedFluoridesGenerationsGoalsIn VitroMapsMedicalMedicationMedicinal ChemistryMedicineMercaptansMercapto CompoundsMethodologyMethodsModelingNegative Beta ParticleNegatronsOrganic SynthesisPharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPharmacodynamicsPharmacokineticsProceduresProcessPropertyProteinsReactionReactive SiteReagentResearchRouteSiteSodium ChlorideSourceStructureSulfhydryl CompoundsSulfone Anti-Infective AgentSulfonesSystemTestingTherapeuticThiolsactivity-based protein profilingbiologiccomputational studiescomputer studiesdevelopmentaldrug candidatedrug efficacydrug marketdrug safetydrug-like chemicaldrug-like compounddrug-like moleculedrug/agentelectronicelectronic devicefallsfunctional groupimprovedin vivoinnovateinnovationinnovativeinsightmedication safetymetabolic profilenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptimismpharmaceutical safetyphysical propertypositive attitudesaltscreeningscreeningssulfhydryl grouptherapeutic candidatetoolvoltage
Description preview
PROJECT SUMMARY
Fluorination of an organic compound affects physicochemical properties, which in medicinal settings
perturbs pharmacodynamic, pharmacokinetic, distribution, and/or metabolic profiles both in vitro and in vivo.
Thus, the ability to selectively install fluorinated groups, such as sulfonyl fluorides (SO2F) and aryl fluorides (ArF),…
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