grant
Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026Animal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArachidonic Acid CyclooxygenaseArachidonic AcidsCationsCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCessation of lifeClinicalClinical ManagementClinical TrialsComplexContracting OpportunitiesContractsCyclo-OxygenaseCyclooxygenaseDataDeathDedicationsDevelopmentDiagnosisDiseaseDisease OutcomeDisease ProgressionDisorderDoctor of PhilosophyEicosanoidsEndothelial CellsEndotheliumExhibitsExperimental DesignsExperimental ModelsFatty Acid Cyclo-OxygenaseFosteringFutureGoalsHETEHumanHydroperoxide CyclaseHydroxyeicosatetraenoic AcidsIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsLaboratoriesLaboratory ProceduresLeadershipLeftLeiomyocyteLifeLinoleate-Oxygen OxidoreductaseLipidsLipoxidaseLipoxygenaseMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentorsMetabolicMetabolic ProcessesMetabolismMethodsModern ManMolecularMorbidityNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingOutcomePGH SynthasePGH2 SynthetasePathogenesisPathogenicityPathway interactionsPatientsPersonalized medical approachPh.D.PhDPhenotypePhysiciansPiezo 1Piezo 1 ion channelPiezo1PlayPreclinical dataPrincipal InvestigatorPrognostic MarkerProgram DevelopmentPropertyProstaglandin Cyclo-OxygenaseProstaglandin CyclooxygenaseProstaglandin Endoperoxide SynthetaseProstaglandin G-H SynthaseProstaglandin H SynthaseProstaglandin H2 SynthetaseProstaglandin SynthaseProstaglandin SynthetaseProstaglandin-Endoperoxide SynthasePulmonary ArteryPulmonary HypertensionPulmonary artery structureReceptor ProteinRelaxationResearchResearch DesignResearch PersonnelResearchersRoleScientistSignal TransductionSignal Transduction SystemsSignalingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStudy TypeStudy modelsSystems BiologyTechniquesTestingTherapeuticTherapeutic InterventionTrainingTraining ProgramsTransfectionVascular remodelingVasodilatationVasodilationVasorelaxationWorkZeugmatographybiological signal transductioncareer developmentcarotene oxidasecell culturecell culturescirculating biomarkerscirculating markersclinical translationclinically translatablecohortcustomized therapycustomized treatmentdata handlingdepositorydevelopmentaldisease riskdisorder riskendothelial dysfunctionexperimentexperimental researchexperimental studyexperimentshemodynamicsimprovedindividualized approachindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentintervention therapylab curriculumlab experiencelab traininglaboratory courselaboratory curriculumlaboratory experiencelaboratory traininglipid mediatorlung vascular remodelinglung vasoconstrictionmetabolism measurementmetabolomicsmetabonomicsmodel of animalmolecular biomarkermolecular markermortalitymouse modelmurine modelnovelpathwaypatient registrypatient specific therapiespatient specific treatmentpersonalized approachprecision approachpreclinical findingspreclinical informationpreventpreventingprognosticprognostic biomarkerprognostic indicatorpulmonary arterial hypertensionpulmonary artery hypertensionpulmonary vascular constrictionpulmonary vascular remodelingpulmonary vasoconstrictionreceptorrelaxing factorrepositoryright heart failureright sided heart failureright ventricle failureright ventricular failureright ventricular heart failureskillssmall moleculesocial rolespecific biomarkersstudy designtailored approachtailored medical treatmenttailored therapytailored treatmentunique treatmentvascular constrictionvasoconstriction
Description preview
PROJECT SUMMARY/ABSTRACT
The objectives of this K08 proposal are to foster the development of critical scientific and professional skills that
will allow the candidate, Dr. Mona Alotaibi, to advance toward her goal of becoming an independent investigator;
and to investigate the role of metabolic dysregulations and bioactive molecular markers of…
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