grant
Effects of the Parkinsons Disease associated protein LRRK2 on lysosomal function and inflammatory activity in microglia
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 9 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025Acid beta-GlucosidaseAddressAffectAwardC5 aC5aCNS Nervous SystemCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineCell SignalingCellLineCellsCentral Nervous SystemCo-cultureCocultivationCocultureCoculture TechniquesComplementComplement 5aComplement C5aComplement ProteinsComplexD-Glucosyl-N-acylsphingosine glucosylhydrolaseDA NeuronDNA mutationDataDefectDevelopment PlansDiseaseDisease ProgressionDisorderDopamineDopamine neuronDysfunctionDyskinesia SyndromesEnzyme GeneEnzymesEsteroproteasesEvaluationExhibitsExposure toFunctional disorderGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetic predisposing factorGlucocerebrosidaseGlucocerebroside beta-GlucosidaseGlucosyl CeramidaseGlucosylceramide beta-GlucosidaseGlucosylsphingosine Glucosyl HydrolaseGoalsHeterozygoteHortega cellHumanHydrolaseHydrolase Family GeneHydrolase GeneHydroxytyramineIFN-GammaIFN-gIFN-γIFNGIFNγIdiopathic Parkinson DiseaseImmuneImmune InterferonImmune systemImmunesImpairmentInduced pluripotencyInduced pluripotent stateInflammatoryInflammatory ResponseInterferon GammaInterferon Type IIIntracellular Communication and SignalingInvestigationKnock-inLRR proteinLRRK2LRRK2 geneLRRK2 leucine-rich repeat kinase 2 geneLRRK2 proteinLeadLinkMacrophageMeasurementMediatorMethodsMicrogliaModern ManMolecularMovement Disorder SyndromesMovement DisordersMutationMyelinMφNAC precursorNerve DegenerationNeuraxisNeuron DegenerationOxidative StressPARK1 proteinPARK4 proteinPARK8 proteinParalysis AgitansParkinsonParkinson DiseaseParkinson disease 8 proteinPathogenesisPathogenicityPathway interactionsPatientsPb elementPeptidasesPeptide HydrolasesPeripheralPhagocytesPhagocytic CellPhagocytosisPhysiciansPhysiopathologyPlayPredispositionPrevalencePrimary ParkinsonismProtease GeneProteasesProteinasesProteolytic EnzymesRNA ExpressionRecombinant C5aRegulationResearchRisk-associated variantRoleSNCASNCA proteinScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStrains Cell LinesStressStructureSubstantia NigraSubstantia nigra structureSusceptibilitySystemTranscriptTranscriptionVariantVariationa-syna-synucleinalpha synucleinalpha synuclein genealphaSP22amebocyteasynbeta-Glucocerebrosidasebiological signal transductioncareercareer developmentcellular differentiationcomplementationcultured cell linecytokinedardarindardarin genedardarin proteindisabilitydopaminergic differentiationdopaminergic neuronextracellulargenetic risk factorgenome mutationgitter cellglucosphingosine glucosylhydrolaseglucosylceramidaseheavy metal Pbheavy metal leadheterozygosityiPSiPSCiPSC technologyiPSCsimmunoneurologyinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell technologyinducible pluripotent cellinducible pluripotent stem cellinherited factorinsightinsoluble aggregateknockinlFN-Gammaleucine-rich repeat kinase 2leucine-rich repeat proteinmesogliamicroglial cellmicrogliocytemutantneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroimmunologyneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationneuroprotectionneuroprotectiveneurotoxicnon A-beta component of AD amyloidnon A4 component of amyloid precursorpathophysiologypathwayperivascular glial cellprogramsprotein aggregateprotein aggregationresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic targettherapy design/developmenttooltranscriptomicstreatment strategyuptakeα synuclein geneα-synα-synuclein
Description preview
Project Summary: Examination of genetic risk factors for Parkinson’s disease (PD) has allowed for the
identification of key mechanisms contributing to the pathogenesis of this disorder. Mutations in the gene
encoding leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial PD and pathogenic
LRRK2 mutations are also found in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click