grant
Effects of arsenic and arsenic-containing mine tailings dust on airway epithelium and susceptibility to mold exposure
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Apr 1997Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY20269-cis-Retinoic Acid ReceptorATRAAddressAffectAreaArsenicBiological MarkersBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsChronicCollaborationsCommunitiesComparative StudyConsumptionDataData AnalysesData AnalysisData Management and Analysis CoreData Management and Statistical Analysis CoreData Management and Statistical CoreDependenceDiseaseDisorderDown-RegulationDustDysfunctionElementsEpithelial CellsEpitheliumEventExposure toFaceFilamentous FungiFoodFunctional disorderGeographic AreaGeographic LocationsGeographic RegionGeographical LocationHealthHealth HazardsHumanHydrogen OxideImmune responseImpairmentIndividualInhalationInhalation ExposureInhalingInjuryIntracellular Communication and SignalingKnowledgeLifeLinkLungLung DiseasesLung Respiratory SystemMediatingMetal exposureMetalsMiceMice MammalsMiningModern ManMoldsMolecularMolecular TargetMucinsMucociliary ClearanceMucociliary TransportMucus GlycoproteinMurineMusNIEHSNational Institute of Environmental Health SciencesNon-MalignantOutcomeParticulate MatterPatternPhysiopathologyPredispositionProcessProductionPublishingPulmonary DiseasesPulmonary DisorderRXRRXR ProteinReportingRepressionResearchResolutionRespiratory EpitheliumRetinoic AcidRetinoic Acid Receptor RXRRetinoid X ReceptorsRiskRisk AssessmentRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStructure of respiratory epitheliumSupplementationSusceptibilityTailTestingTissuesToxic effectToxicitiesToxicokineticsToxicologyTrans Vitamin A AcidTretinoinTretinoinumVitamin A AcidWaterairway epitheliumall-trans-Retinoic Acidall-trans-Vitamin A acidarsenicsbio-markersbiologic markerbiological signal transductionbiomarkercausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typeco-exposuresco-occurring exposurecombined exposurecommunity livingcomplex exposureconcurrent exposuredata interpretationdisease of the lungdisorder of the lungenvironmental stressesenvironmental stressorexposed human populationexposure mixtureexposure to metalfacesfacialgeographic sitehazardhost responsehuman exposureimmune system responseimmunoresponsein vivoinjuriesinsightlung disorderlung functionlung healthmetal poisoningmetal toxicitymixed exposuremouse modelmurine modelnonmalignantpathophysiologypulmonarypulmonary functionpulmonary healthresolutionsrespiratory tract epitheliumresponsescRNA sequencingscRNA-seqsimultaneous exposuressingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuperfund sitetoxic metaltrans-Retinoic Acidwasting
Description preview
PROJECT SUMMARY (Project 1: Chen)
Chronic exposure to arsenic (As), commonly found in mine tailings particulate matters (mt-PMs), heightens the
risk of lung diseases. This risk is notably elevated for those living near contaminated sites due to continuous
exposure from inhaling dust and consuming tainted water or food. Additionally,…
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