grant
Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 5 Jul 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AchievementAchievement AttainmentAdipose tissueAdult-Onset Diabetes MellitusAgeAttenuatedBMIBMI percentileBMI z-scoreBathingBathsBiopsyBody TissuesBody Weight decreasedBody mass indexCell Communication and SignalingCell SignalingClampingsClinicalClosure by clampCold-Insoluble GlobulinsDataDevelopmentDiabetes MellitusEicosanoidsEthnic OriginEthnicityEuglycemic ClampingEuglycemic-hyperinsulinemic ClampExtracellular Matrix ProteinsFN1Fatty TissueFibronectin 1FibronectinsFree Fatty AcidsFutureGlucose ClampHealthHumanHumulin RHyperinsulinemic ClampIn VitroIndividualInflammationInflammatoryInflammatory ResponseInsulinInsulin ResistanceInterventionIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusLETS ProteinsLarge External Transformation-Sensitive ProteinLifeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMarbleMaturity-Onset Diabetes MellitusMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic dysfunctionMissionModern ManMuscleMuscle FibersMuscle TissueMyotubesNIDDMNMR ImagingNMR TomographyNational Institutes of HealthNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonesterified Fatty AcidsNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNuclear Magnetic Resonance ImagingObesityOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOutcomeParacrine CommunicationParacrine SignalingPlayPositionPositioning AttributePublic HealthQuetelet indexRegular InsulinResearchRhabdomyocyteRiskRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSlow-Onset Diabetes MellitusStable Diabetes MellitusT2 DMT2DT2DMTechniquesTestingTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of HealthVisceralVoluntary MuscleWeight LossWeight ReductionZeugmatographyadipocytokinesadipokinesadiposeadiposityadult onset diabetesagesalpha 2-Surface Binding Glycoproteinattenuateattenuatesbiological signal transductionbody weight losscombatcorpulencecytokinedevelop therapydevelopmentaldiabetesdisabilityexperimentexperimental researchexperimental studyexperimentsimprovedinnovateinnovationinnovativeinsulin resistantinsulin sensitivityinsulin toleranceintervention developmentketosis resistant diabeteslife style interventionlifestyle interventionmaturity onset diabetesmuscularnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobese individualsobese peopleobese personobese populationobese subjectsobesity riskpreventpreventingresponserisk for obesityrisk of obesitysexsocial roletherapeutic targettherapy developmenttreatment developmenttype 2 DMtype II DMtype two diabetesultrasoundweight loss interventionweight loss therapyweight loss treatmentwhite adipose tissuewt-lossyellow adipose tissue
Description preview
Intermuscular adipose tissue (IMAT) is marbled within skeletal muscle and appears to play a key role in the
obesity-induced risk of type 2 diabetes. What is not known is how IMAT promotes decreased muscle insulin
sensitivity. There is a critical need to understand how IMAT contributes to the risk of obesity-induced diabetes,
and how to intervene…
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