grant
Effect of SARS-CoV-2 on host metabolism and its influence on innate and adaptive immunity
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old2019 novel corona virus2019 novel coronavirus2019-nCoVAgeAnimalsBody TissuesCOVID-19 immunityCOVID-19 infectionCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 virusCause of DeathCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChildChild YouthChildren (0-21)CoV-2CoV2Communicable DiseasesDataDeathDevelopmentDiseaseDisease ProgressionDisorderDrugsElementsEnvironmentFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGenerationsGenomicsGoalsHumanImaging technologyImmuneImmune responseImmunesImmunityIn VitroInfectionInfectious DiseasesInfectious DisorderInflammationInflammatory ResponseInnate Immune ResponseInnate ImmunityIntermediary MetabolismLipidsLocationLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Lower Respiratory Tract InfectionLower respiratory infectionLungLung Respiratory SystemLung infectionsMediatorMedicationMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMurineMusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityObesityOrganPathogenesisPathway interactionsPeripheralPersonsPharmaceutical PreparationsPhenotypePopulationPrimary InfectionProductionResolutionRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 immunitySARS-CoV-2 infectionSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 immunitySevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2Subcellular ProcessSymptomsT-CellsT-LymphocyteTechniquesTelemetriesTelemetryTherapeuticTherapeutic InterventionTissuesVaccinationVaccinesVirionVirusVirus ParticleWuhan coronavirusadaptive immune responseadaptive immunityadiposityafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionagesanimal imagingcell typechronic COVIDchronic COVID-19chronic novel coronavirus disease 2019co-morbidco-morbiditycomorbiditycoronavirus disease 2019 immunitycoronavirus disease 2019 infectioncoronavirus disease 2019 viruscoronavirus disease-19 viruscorpulencedevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesitydrug/agentearly clinical trialearly phase clinical trialexperienceflow cytophotometryfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionhCoV19host responseimmune system responseimmunity against COVID-19immunity against SARS-CoV-2immunity against Severe acute respiratory syndrome coronavirus 2immunity against coronavirus disease 2019immunity to COVID-19immunity to SARS-CoV-2immunity to Severe acute respiratory syndrome coronavirus 2immunity to coronavirus disease 2019immunoresponsein vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2insightintervention therapykidslipid mediatorlipidomicslong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019lung functionlung pathogenmetabolism measurementmetabolomicsmetabonomicsmodel developmentmodel developmentsmouse modelmultiomicsmultiple omicsmurine modelnCoV2new drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnew vaccinesnext generation therapeuticsnext generation vaccinesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetnovel vaccinespandemicpandemic diseasepanomicspathogenpathwaypersistent COVID-19post COVID syndromepost COVID-19 syndromepost SARS-CoV-2 infectionpost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19preventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprolonged COVID-19 symptomspulmonarypulmonary functionpulmonary infectionspulmonary pathogenresolutionssecondary infectionsocial roletelemetrictemporal measurementtemporal resolutionthymus derived lymphocytetime measurementyoungster
Description preview
Pulmonary infections represent 5 of the 30 most common causes of death around the world, with lower respiratory infections resulting on average of 4 million deaths each year and the leading cause of death among children under the age of 5. We are currently in the midst of a pandemic caused by the pulmonary pathogen SARS-CoV-2. Since this is a new…
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