grant
Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell Metabolism
Organization EAST CAROLINA UNIVERSITYLocation GREENVILLE, UNITED STATESPosted 9 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase21+ years old5 year old5 years of age5'-AMP-activated protein kinaseACOGAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAdipocytesAdipose CellAdultAdult HumanAdverse effectsAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessAffectAge MonthsAmerican College of Obstetricians and GynecologistsAmerican College of Obstetricians and GynecologyAmerican College of Obstetrics and GynecologistsAmerican College of Obstetrics and GynecologyAncillary StudyBMIBMI percentileBMI z-scoreBasal MetabolismBasal metabolic rateBeta CellBioenergeticsBloodBlood Reticuloendothelial SystemBody CompositionBody TissuesBody fatBody mass indexCandidate Disease GeneCandidate GeneCellular Metabolic ProcessD-GlucoseDEXADXADataDepositDepositionDextroseDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryEnergy ExpenditureEnergy MetabolismEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExerciseExposure toFat CellsFatsFatty acid glycerol estersGSK-3betaGSK-3βGenerationsGenesGestationGlucoseHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHealthHumanHumulin RIndirect CalorimetryInfantInfant HealthInsulinInsulin CellInsulin Secreting CellIntermediary MetabolismInvestigatorsLifeLipidsLipocytesLong-term prospective studiesMature LipocyteMature fat cellMeasuresMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMesoderm CellMesodermal CellMetabolicMetabolic ProcessesMetabolismMitochondriaModelingModern ManMothersMuscle CellsMyocytesNovolin RObesityOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayParentsPathway interactionsPhenotypePregnancyPregnant WomenProductionProteinsPublishingQuetelet indexR-Series Research ProjectsR01 MechanismR01 ProgramRandomizedRecommendationRegular InsulinResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRespiration CalorimetryRestRiskRoleTestingTissuesTranslatingTriacylglycerolTriglyceridesUmbilical CordUmbilical cord structureWeightWomanWorkadipogenesisadiposityadulthoodadverse consequenceadverse outcomeage 5age 5 yearscandidate identificationcare as usualcell metabolismcell typecellular metabaolismchild adipositychild obesitychildhood adipositychildhood obesitycorpulenceenrollepigeneticallyexercise modalitiesexpectant motherexpectant womenexpecting motherexpecting womenfetalfive year oldfive years of ageglycogen synthase kinase 3 betaglycogen synthase kinase 3βhydroxymethylglutaryl-CoA-reductase kinaseimprovedindexingindividuals who are pregnantinsulin sensitivitylife style interventionlifestyle interventionlipid biosynthesislipogenesislongitudinal, prospective studymaternal adipositymaternal obesitymesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmetabolic profilemetabolism measurementmetabolomicsmetabonomicsmethylation patternmitochondrialmode of exercisemultiomicsmultiple omicsmyogenesisobese childrenobesity during childhoodobesity during pregnancyobesity in childrenobesity in pregnancyobesity riskoffspringoxidationpanomicsparentparent grantpathwaypediatric obesitypeople who are pregnantpostnatalpregnantpregnant femalespregnant motherspregnant peoplepregnant populationsprogenitor cell modelprogenitor modelrandomisationrandomizationrandomly assignedresistance exerciseresistance trainingrespiratoryresting metabolic raterisk for obesityrisk of obesitysedentarysocial rolestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelthose who are pregnanttreatment as usualusual careweightswomen who are pregnantβ-cellβ-cellsβCell
Description preview
Project Summary
Obesity in pregnancy increases the risk for excessive adiposity in offspring, which tracks into adulthood and
can perpetuate across generations. Our preliminary data and published studies indicate that exercise initiated
during pregnancy in sedentary women with obesity lowers infant BMI z-scores and body fat percentage. These…
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