grant
Ecology and genetics of insecticide resistance in African malaria vectors
NIHUS FederalResearch GrantFY20250-11 years oldAfricaAfrica South of the SaharaAfricanAgeAreaBedsBehaviorBiochemicalBionomicsBiteChildChild YouthChildren (0-21)ComplexCountryCountyCulicidaeCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneDNA mutationDataDevelopmentDoseDrosophilaDrosophila genusDrug Metabolic DetoxicationDrug Metabolic DetoxificationEcologyEffectivenessEnzyme GeneEnzyme InhibitionEnzymesEvolutionExposure toFeeding behaviorsFrequenciesGene FamilyGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenotypeGoalsHeterogeneityHistoryHumanIngestive BehaviorInsecticide ResistanceInsecticidesKenyaMalariaMeasuresMediatingMetabolicMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMethodsModern ManMosquitoesMutationOutcomeP450PaludismPatternPersonsPhenotypePlasmodium InfectionsPopulationProductionRNA ExpressionRNA SeqRNA sequencingRNAseqRecording of previous eventsResidualResidual stateResistanceRestRiskRoleSaharaShapesSiteSub-Saharan AfricaSubsaharan AfricaTranscriptionTransmissionVariantVariationVector Ecologyagesdensitydetoxificationdevelopmentalfeeding-related behaviorsfruit flygenome mutationgenome scalegenome-widegenomewidehistoriesinsecticide resistantkidsnext generationnutrient intake activityprospectivepublic health relevancepyrethroidresistance strainresistantresistant strainresponsescale upsocial rolespatial and temporalspatial temporalspatiotemporalsynergismtranscriptome sequencingtranscriptomic sequencingtranscriptomicstransmission processvectorvector bionomicsvector controlvector transmissionyoungster
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Project summary
Title: Ecology and genetics of insecticide resistance in African malaria vectors
The current first-line vector control methods rely on pyrethroid-based long-lasting insecticidal nets (LLINs) and
indoor residual spraying (IRS). Insecticide-resistant vector genotypes are selected, leading to widespread of
insecticide resistance in…
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