grant
Early response to radiotherapy and immunotherapy in rectal cancer: an integrated molecular, cellular, and spatial approach
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AccelerationAgonistAnimal ModelAnimal Models and Related StudiesAntibodiesBiopsyBody TissuesBp50CD40CDW40CancersCell Communication and SignalingCell SignalingChemotherapy and RadiationChemotherapy and/or radiationClinicalClinical TrialsClinical assessmentsColorectal CancerCombination immunotherapyComplexCoupledData SetDendritic CellsDevelopmentDisease ManagementDisorder ManagementEvaluationEventExperimental ModelsFutureHistologicHistologicallyHumanImmuneImmune TargetingImmune mediated therapyImmune responseImmune signalingImmunesImmunofluorescenceImmunofluorescence ImmunologicImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIn complete remissionIncidenceIndividualInduction TherapyInnate Immune ResponseIntracellular Communication and SignalingKnowledgeLearningLocal TherapyLocalized TherapyMGC9013MMR deficiencyMalignant NeoplasmsMalignant TumorMapsMismatch Repair DeficiencyModelingModern ManMolecularNEOADJNeighborhoodsNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentOperative ProceduresOperative Surgical ProceduresPathway interactionsPatient SelectionPatientsPharmacodynamicsPhasePopulationProteomicsRadiationRadiation therapyRadiotherapeuticsRadiotherapyRandomization trialReceptor ProteinRectal CancerRectal CarcinomaRisk ReductionSYS-TXSignal TransductionSignal Transduction SystemsSignalingSurgicalSurgical InterventionsSurgical ProcedureSystemic TherapyTNFRSF5TNFRSF5 geneTechnologyTherapeuticTherapeutic EffectTissuesTumor Necrosis Factor Receptor Superfamily Member 5 GeneTumor TissueValidationVeiled Cellsadaptive immune responseanti-cancer immunotherapyanti-tumor immune responseanticancer immunotherapybiological signal transductioncancer immunotherapycancer microenvironmentchemo/radiation therapychemotherapychemotherapy and radiotherapycombinatorial immunotherapycomplete responsecurative interventioncurative therapeuticcurative therapycurative treatmentsdeep learningdeep learning methoddeep learning strategydevelop therapydevelopmentaldual immunotherapyefficacy testingenhancing factorevidence basehigh riskhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapy for cancerimmunotherapy of cancerimmunotherapy trialsimprovedimproved outcomeindividualized cancer careindividualized oncologyinduction therapiesinnovateinnovationinnovativeinsightintervention developmentirradiation responsemalignancymodel of animalneoplasm/cancernovelp50participant enrollmentpathwaypatient enrollmentpatient populationpatient responsepatient specific responsepermissivenesspersonalization of treatmentpersonalized medicinepersonalized oncologypersonalized therapypersonalized treatmentphase 2 trialphase II trialprecision cancer careprecision cancer medicineprecision oncologyradiation or chemotherapyradiation responseradiation treatmentrandomized trialrandomized, clinical trialsreceptorreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponders and non-respondersresponders from non-respondersresponders or non-respondersresponders versus non-respondersresponders vs non-respondersresponders/nonrespondersresponseresponse to radiationresponse to therapyresponse to treatmentresponsive patientrisk-reducingscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsuccesssurgerysynergismtherapeutic responsetherapy developmenttherapy responsetreatment developmenttreatment responsetreatment responsivenesstreatment with radiationtrial designtumortumor microenvironmentvalidations
Description preview
Project Abstract
With increased incidence in young populations and ~65% three-year survival of high-risk locally advanced rec-
tal cancer, innovative approaches to improve outcomes is imperative. Neoadjuvant therapy with radiation (RT)
and chemotherapy (CT) is now the standard curative treatment, but there is demand for non-operative man-
agement…
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