grant
Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 19 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffectAnti-viral TherapyAntibody TherapyAntigenic DeterminantsB-Cell Chronic Lymphocytic Leukemia Associated OncogeneB-cell Leukemia 1BCLBCL1 OncogeneBinding DeterminantsBlood PlasmaCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell FunctionCell PhysiologyCell ProcessCell Surface ProteinsCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessClinical TreatmentClinical TrialsDevelopmentDisease remissionEarly InterventionEngraftmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitopesExpression SignatureFrequenciesFutureGene Expression ProfileGoalsHIVHIV InfectionsHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHeterograftHeterologous TransplantationHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1IFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune mediated therapyImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyIndividualInfectionInfusionInfusion proceduresInterferon GammaInterferon Type IIInterruptionInterventionLAV-HTLV-IIILymphadenopathy-Associated VirusMeasuresMediatingModern ManNIAIDNational Institute of Allergy and Infectious DiseaseOutcomeParticipantPersonsPhasePhenotypePlasmaPlasma SerumPolandPropertyRemissionReportingResistanceReticuloendothelial System, Serum, PlasmaSamplingSubcellular ProcessSystemT cell responseT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTeff cellTherapeuticTimeUniversitiesValidationViralViral reservoirVirusVirus reservoirVirus-HIVXenograftXenograft procedureXenotransplantationadaptive immune responseantagonismantagonistantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentantiretroviral therapyantiretroviral treatmentclinical interventionclinical therapydevelopmentaleffector T cellepigeneticallyfeature selectiongene expression patterngene expression signaturehost responsehumanized micehumanized mouseimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimprintimprovedin vivoinfusionslFN-Gammamouse modelmurine modelneutralizing antibodynovelpreservationresistantresponsesuccessthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptomicstrial regimentrial treatmentvalidationsviral infectious disease treatmentxeno-transplantxeno-transplantation
Description preview
Increasing efforts are being made to understand whether early intervention after HIV-1 infection can enable long-
term viral control and reduction of the viral reservoir through the preservation of HIV-1-specific immune
responses. Recently, the pioneering eCLEAR phase 1b/2a clinical trial led by MPI SØgaard, found that
administration of the…
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