grant
Early identification of immunotherapy resistance through integrated multiparameter imaging
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026After CareAfter-TreatmentAftercareAutoimmune StatusAutoimmunityAutomobile DrivingB7-H1Blood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCD274CD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCSF3CSF3 geneCT-26CT26CXCL1CXCL1 geneCancer ModelCancer PatientCancerModelCancersCell BodyCell Communication and SignalingCell SignalingCell-Mediated Lympholytic CellsCellsCheckpoint inhibitorChemotherapy and RadiationChemotherapy and/or radiationChronicClinicalColorComplexCustomCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDataDevelopmentDisease ProgressionDrugsEarly identificationElementsEngineeringExhibitsFDA approvedFeedbackFluorescenceFutureG-CSFGCSFGRO1GROAGoalsGranzymeHead and Neck CancerHead and Neck CarcinomaHeterogeneityIL-1IL1ImageImaging technologyImmune MarkersImmune checkpoint inhibitorImmune mediated therapyImmune responseImmunologic MarkersImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImplantInflammationInflammation MediatorsInflammatoryInflammatory ResponseInterleukin IInterleukin-1InterventionIntracellular Communication and SignalingKnowledgeLYT3Lymphocyte-Stimulating HormoneMGC45931MGSAMacrophage Cell FactorMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant TumorMarrow NeutrophilMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMediatingMedicationMiceMice MammalsModelingModificationMonitorMultiplexed Ion Beam ImagingMurineMusMyeloid-derived suppressor cellsNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOncologyOncology CancerOutcomePD 1PD-1PD-L1PD1PDL-1PETPET ScanPET imagingPETSCANPETTPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmaceutical PreparationsPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProductionProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1PropertyProteinsRad.-PETRadiographyReportingResistanceResolutionRoentgenographyRoleSCYB1ScanningSignal TransductionSignal Transduction SystemsSignalingT Helper FactorT cell infiltrationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTechniquesTestingTimeTissue imagingTissuesToxic effectToxicitiesTranslatingTumor CellTumor ImmunityTumor Tissueanti-cancer immunotherapyanti-tumor immunityanticancer immunotherapyantitumor immunitybiological signal transductioncancer imagingcancer immunitycancer immunotherapycancer microenvironmentcell typechemo/radiation therapychemotherapy and radiotherapycontinuous monitoringcustomscytokinecytotoxicdevelopmentaldrivingdrug/agentfluorescence imagingfluorescent imaginghead/neck cancerhigh dimensionalityhost responseimage-based methodimagerimagingimaging approachimaging based approachimaging in vivoimaging methodimaging modalityimmune check point inhibitorimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based biomarkersimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunological biomarkersimmunological markersimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimmunotherapy for cancerimmunotherapy of cancerimprovedimproved outcomein vivoin vivo fluorescence imagingin vivo imagingin-vivo fluorescence imaginginflammatory mediatorinnovateinnovationinnovativeinsightkiller T celllymphocyte activating factormalignancymalignant head and neck tumormolecular imagingmolecule imagingmouse modelmulti-modalitymultimodalitymurine modelmyeloid suppressor cellsmyeloid-derived suppressive cellsneoplasm/cancerneoplastic cellneutrophilnon-invasive imagingnoninvasive imagingnovelnovel imaging technologyoncologic imagingoncology imagingpathwaypatient oriented outcomespatient responsepatient specific responsepersonalized immunotherapypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost treatmentprecision immunotherapyprecision medicineprecision-based medicinepredict responsivenesspredicting responseprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1protein death-ligand 1radiation or chemotherapyradiological imagingreal time monitoringreal-time imagesrealtime imagerealtime monitoringrecruitrepurposingresistance mechanismresistantresistant mechanismresolutionsresponseresponsive patientsensorsle2social rolesuccesssuppressive myeloid cellssynergismsystemic lupus erythematosus susceptibility 2therapy optimizationthymus derived lymphocytetreatment optimizationtumortumor imagingtumor microenvironment
Description preview
PROJECT SUMMARY
Immunotherapies for cancer have revolutionized oncology, but most patients do not experience durable
responses. Immune checkpoint inhibitors targeting PD-1 and PD-L1 are now FDA-approved for a wide variety of
tumors, but non-invasive strategies to monitor response and identify mechanisms of resistance have not yet
been developed.…
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