grant
Early Developmental Risk for Adult Cardiovascular Disease: High risk Subgroups, Biomarkers, and Mechanisms
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years old3rd trimesterActive Follow-upAddressAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAgeAge YearsAmino-terminal pro-brain natriuretic peptideAtherogenicityBarker HypothesisBiological MarkersBlood DiseasesBlood SerumBostonCardiacCardiac DiseasesCardiac DisordersCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCells Placenta-TissueChronicChronologic Fetal MaturityClinicalClinical assessmentsCommunitiesCoronary DiseaseCoronary heart diseaseD-GlucoseDataDevelopmentDextroseDiabetes MellitusDiseaseDisease OutcomeDisease ProgressionDisorderDysfunctionDyslipidemiasECSFEarly InterventionEarly identificationEnrollmentEpoetinErythropoietinFLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFamily StudyFeBADFetal AgeFetal Basis of Adult DiseaseFetal Origin of Adult DiseaseFingerprintFlt-1Functional disorderGestationGestational AgeGlucoseHDLHDL LipoproteinsHealthHeartHeart DiseasesHeart VascularHeavy LipoproteinsHematologic DiseasesHematological DiseaseHematological DisorderHeterogeneityHigh Density LipoproteinsHypertensionImpairmentIndividualInfantInterventionKnowledgeLast TrimesterLifeLinkLipidsLongitudinal StudiesLungLung DiseasesLung Respiratory SystemMalnutritionMeasuresMetabolicMothersN-BNP peptideN-terminal pro-BNPNHLBINT-BNPNT-proBNPNational Heart, Lung, and Blood InstituteNational Institutes of HealthNew EnglandNormal PlacentomaNortheastern United StatesNutritional DeficiencyObesityOnset of illnessOrigin of Adult DiseasePGF genePLGF-2ParticipantPerinatalPeripartumPhysiopathologyPlGFPlGF proteinPlacentaPlacenta Embryonic TissuePlacental Growth FactorPlacentomePregnancyPregnant WomenPreventionProto-Oncogene Protein fltPublic HealthPublishingPulmonary DiseasesPulmonary DisorderReceptor Tyrosine Kinase,Class VRiskRisk FactorsSamplingSerumSerum MarkersSiteSleep DisordersSmall for Gestational Age InfantStructureSubgroupThird Pregnancy TrimesterThird TrimesterTriacylglycerolTriglyceridesTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTUmbilical CordUmbilical cord structureUndernutritionUnited States National Institutes of HealthVEGF Receptor flt-1 ProteinVEGFR-1VEGFR1Vascular Endothelial Growth Factor Receptor-1Vascular Hypertensive DiseaseVascular Hypertensive DisorderWorkactive followupadiposityadjudicationadjudicative process and procedureadulthoodagedagesalpha-Lipoproteinsbio-markersbiologic markerbiomarkerblood disordercardiac disease riskcardiac disorder riskcardiac functioncardiovascular disease riskcardiovascular disordercardiovascular disorder riskcirculatory systemcohortcoronary artery calciumcoronary calciumcoronary disordercorpulencedevelopmentaldiabetesdietary deficiencydisease of the lungdisease onsetdisease preventiondisorder of the lungdisorder onsetdisorder preventionenrollerythrocyte colony stimulating factorexpectant motherexpectant womenexpecting motherexpecting womenexperiencefetalfetal hypoxiafetal programmingfetus hypoxiafms-Like Tyrosine Kinasefollow upfollow-upfollowed upfollowupfunction of the heartheart disease riskheart disorderheart disorder riskheart functionhematopoietinhigh blood pressurehigh riskhyperpiesiahyperpiesishypertensive diseasehypertensive disorderindividuals who are pregnantinsightlater in lifelater lifelife spanlifespanlong-term studylongitudinal outcome studieslung disordermalnourishedmaternal serummetabolism measurementmetabolomicsmetabonomicsmortalitymultidisciplinarynutrient deprivationnutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritional deprivationoffspringpathophysiologypeople who are pregnantplacenta growth factorpregnant femalespregnant motherspregnant peoplepregnant populationsprenatalprimary outcomepro-brain natriuretic peptide (1-76)proBNP(1-76)product placenta growth factorprospectiverecruitscreeningscreeningssecondary outcomesleep diseasessleep dysfunctionsleep illnesssleep problemsmall for gestational agethose who are pregnantunbornvasculogenesiswomen who are pregnant
Description preview
This project seeks to generate new insights – of clinical and public/health/relevance – regarding
the early identification and prevention of adult coronary heart disease (CHD). It is well known
that 10% of infants born small for gestational age (SGA), compared to average for gestational
infants (AGA), are at increased risk for later life CHD…
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