grant
Early cardiac progenitors
Organization J. DAVID GLADSTONE INSTITUTESLocation SAN FRANCISCO, UNITED STATESPosted 1 Jul 2013Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-11 years old3-D3-Dimensional3DARP1 proteinATAC sequencingATAC-seqATACseqAffectAnteriorAssay for Transposase-Accessible Chromatin using sequencingAtrialBasal Transcription FactorBasal transcription factor genesBehaviorBindingBirthBirth DefectsBrachydanio rerioCOUP transcription factor IICOUP-TF IICOUP-TFIICRISPRCRISPR/Cas systemCardiacCardiac AtriumCardiac developmentCause of DeathCell BodyCell NucleusCellsCharacteristicsChildChild YouthChildren (0-21)ChromatinClustered Regularly Interspaced Short Palindromic RepeatsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital Cardiac DefectsCongenital DefectsCongenital DeformityCongenital Heart DefectsCongenital MalformationCoupledDNA mutationDanio rerioDataData AnalysesData AnalysisDefectDeletion of DNA SequencesDevelopmentEmbryoEmbryonicGATA binding protein 4GATA4GATA4 geneGATA4 transcription factorGene Action RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenome engineeringGoalsHeartHeart AtriumHeterozygoteHumanHypoplastic Left Heart SyndromeHypoplastic Left VentricleImageInfant MortalityInfant Mortality TotalInstructionInterrupted Aortic ArchLabelLeftLeft VentriclesLeft ventricular structureLinkLocationMEF-2CMEF2C proteinMachine LearningMesodermMiceMice MammalsModelingModern ManMolecularMolecular InteractionMorphogenesisMorphologyMurineMusMutateMutationNR2F2NatureNucleusOrganogenesisOrganoidsParturitionRNA SeqRNA sequencingRNAseqRegulationRegulatory ElementReporterResearch SpecimenRight VentriclesRight ventricular structureSamplingSequence DeletionSpecimenStem cell in the heartStructureSystemTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor Proto-OncogeneTranscription factor genesTransgenic OrganismsTubeVentricularVisualizationZebra DanioZebra FishZebrafishanalyze gene expressionapoAI regulatory protein-1apolipoprotein AI regulatory protein 1assay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingatriumcardiac imagingcardiac progenitorcardiac scanningcardiac stem cellcardiogenesiscell engineeringcellular engineeringchicken ovalbumin upstream promoter-transcription factor IIcofactordata interpretationdeath among infantsdeath in first year of lifedeath in infancydeath in infantsdevelopmentalepigenomicsexperimentexperimental researchexperimental studyexperimentsgene expression analysisgene expression assaygene regulatory networkgenome mutationgenomic deletionheart cellheart developmentheart formationheart imagingheart progenitorheart scanningheart stem cellheterozygosityhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypoplastic left hearthypoplastic left syndromeimaginginduced human pluripotent stem cellsinfant deathinfant demiseinfantile deathkidsmachine based learningmorphogenetic processmortality in infantsmultiomicsmultiple omicsmyocyte enhancer factor 2Cmyocyte-specific enhancer-binding-factor 2Cnovelnuclear receptor subfamily 2, group F, member 2panomicsthree dimensionaltranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtransgenicyoungster
Description preview
PROJECT SUMMARY
Transcription factor (TF) mutation underlie many birth defects, including congenital heart defects (CHD).
Many of the transcription factors mutated in CHD are active very early in development, in some cases prior
to organogenesis. For example, NKX2-5, TBX5, and GATA4 . These transcription factors, along with their
partner TFs, such…
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