grant
Dysfunctional Renin-Angiotensin System in Septic Shock
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 15 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025ACE2After CareAfter-TreatmentAftercareAldosteroneAngIIAngiotensin Converting EnzymeAngiotensin I-Converting EnzymeAngiotensin IIAngiotensin-Forming EnzymeAngiotensinogenAngiotensinogenaseAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAttenuatedBig ReninBioassayBiological AssayBiological MarkersBlindedBlood PlasmaBlood PressureBlood SampleBlood SerumBlood monocyteBlood specimenBody SystemBody TissuesCD143 AntigensCarboxycathepsinCaringCell Communication and SignalingCell SignalingCellular Immune FunctionCirculatory CollapseClinicalClinical TrialsCryoreninDataDeath RateDipeptidyl Peptidase ADiseaseDisease ManagementDisease OutcomeDisorderDisorder ManagementDrug ModulationDrugsDysfunctionEnrollmentEquilibriumEventFunctional disorderGene ExpressionHealth CareHumanHypertensinogenHypotensionImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInactive ReninInfectionInflammationInterventionIntracellular Communication and SignalingInvestigationKininase AKininase IILevarterenolLevonorepinephrineLifeLiquid substanceLow Blood PressureMarrow monocyteMeasurementMeasuresMediatingMedicationMiceMice MammalsMiscellaneous AntibioticModern ManMolecularMurineMusNoradrenalineNorepinephrineOrganOrgan SystemOutcomeOutputPBMCPathogenicityPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeptidyl-Dipeptidase APerfusionPeripheral Blood Mononuclear CellPharmaceutical PreparationsPhysiologicPhysiologicalPhysiopathologyPlacebosPlasmaPlasma SerumPrediction of Response to TherapyProangiotensinPrognosisProreninProteinsRandomization trialRandomizedReceptor ProteinRegulationReninRenin-Angiotensin SystemRenin-Angiotensin-Aldosterone SystemRenin-SubstrateResuscitationReticuloendothelial System, Serum, PlasmaRiskSamplingSepsisSeptic ShockSerumSeveritiesSeverity of illnessSham TreatmentShockSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSpecific qualifier valueSpecifiedStagingStimulusSubgroupSystems BiologyTestingTherapeutic InterventionTimeTissuesTreatment ProtocolsTreatment RegimenTreatment ScheduleVascular Hypotensive DisorderVasoactive AgonistsVasoconstrictor AgentsVasoconstrictor DrugsVasoconstrictorsVasodilatationVasodilationVasopressor AgentsVasorelaxationWorkanalyzing longitudinalangiotensin converting enzyme 2angiotensin converting enzyme IIantisepsis treatmentattenuateattenuatesbalancebalance functionbio-markersbiologic markerbiological signal transductionbiomarkercirculating biomarkerscirculating markerscirculatory shockclinical relevanceclinically relevantcustomized therapycustomized treatmentdisease severitydrug/agentenrollfluidglobal healthhost responsehypoperfusionimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedimproved outcomeindividualized biomarkersindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentindividuals with sepsisinnate immune functioninsightintervention therapyliquidlongitudinal analysismonocytemortalitymortality ratemortality ratiomultidisciplinarynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypatient oriented outcomespatient specific therapiespatient specific treatmentpatients with sepsispeople with sepsispersonalized biomarkerspost treatmentpredict therapeutic responsepredict therapy responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary outcomerandomisationrandomizationrandomized trialrandomized, clinical trialsrandomly assignedreceptorresponserestorationscRNA sequencingscRNA-seqsepsis caresepsis groupssepsis interventionssepsis managementsepsis patientssepsis populationsepsis subjectssepsis therapeuticssepsis therapysepsis treatmentseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectseptic therapyseptic treatmentsham therapyshockssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstandard of caresubjects with sepsistailored medical treatmenttailored therapytailored treatmenttherapeutic agent developmenttherapeutic developmenttherapy predictiontreat sepsistreatment predictiontreatment response predictiontrial comparingunique treatmentvasopressor
Description preview
Scientific Abstract:
Sepsis and septic shock are global healthcare problems associated with mortality rates of up to 40% despite
best therapy efforts. Circulating markers of septic shock severity may constitute a clinically relevant approach
to individualize therapy and resuscitation for those patients at risk for poor outcomes early in the course…
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