grant
Dynamics of the cellular interactome
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 May 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AgingAutomobile DrivingCancer TreatmentCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell SurvivalCell ViabilityCellsChemicalsComprehensionCrowdingDevelopmentDiseaseDisorderEnvironmentEnvironmental FactorEnvironmental Risk FactorEukaryotic CellExposure toFutureGoalsHSF1HSP-90HSP90Heart VascularHeat StressHeat-Shock Proteins 90InformaticsIonic StrengthsIonsLigandsMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetabolicMethodsMitochondriaMitochondrial DiseasesMitochondrial DisordersMolecularNerve DegenerationNeuron DegenerationNutrientOxidative StressPathway interactionsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProkaryotaeProkaryotic CellsProtein ConformationProtein ModificationProteinsProteomeReporterShapesStressTechnologyTemperatureanti-cancer therapybiological adaptation to stresscancer therapycancer typecancer-directed therapycirculatory systemcofactorcrosslinkdevelopmentaldrivingenvironmental riskfitnesshsp90 Familyhuman diseaseimprovedin vivoinhibitorinsightintermolecular interactionmitochondrialneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelpathwaypressureprokaryoteprotein protein interactionreaction; crisisstress responsestress; reaction
Description preview
Cellular functional pathways have evolved through selective pressures and fitness benefits conferred through
protein intra- and inter-molecular interactions that comprise all protein conformational features and protein-
protein interactions, collectively referred to as the interactome. While the interactome is regulated by proteome
levels, it is…
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