grant
Dynamics of Hippocampal Inputs in Alzheimer's Disease
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 18 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202665 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD modelAD pathwayAD therapyAD treatmentAD-associated pathwaysAD-related pathwaysAD-specific pathwaysAddressAdvisory CommitteesAffectAgeAged 65 and OverAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease mechanismAlzheimer disease treatmentAlzheimer pathwayAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's disease modelAlzheimer's disease therapyAlzheimer's mechanismAlzheimer's related pathwaysAlzheimer's therapyAlzheimers DementiaAmmon HornAreaAutomobile DrivingCause of DeathChronicCognitionCornu AmmonisCyclic SomatostatinDataDysfunctionElectrophysiologyElectrophysiology (science)Entorhinal AreaEnvironmentFacultyFire - disastersFiresFunctional disorderFutureGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHippocampusImpairmentInterventionLearningMapsMeasuresMedialMemoryMemory DeficitMemory LossMemory impairmentMentorsMentorshipMiceMice MammalsMurineMusNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronal DysfunctionNeuronsNeurophysiology / ElectrophysiologyParvalbuminsPathway interactionsPatternPhasePhysiopathologyPlayPopulationPositionPositioning AttributePrimary Senile Degenerative DementiaQualifyingResearchResearch ResourcesResourcesRestRetrievalRoleSRIHSRIH-14SomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneTask ForcesTechniquesTestingTrainingUniversitiesabove age 65advisory teamafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardagedaged 65 and greateraged 65+aged ≥65agesalzheimer modelcostdrivingelectrophysiologicalentorhinal cortexevidence baseexperimentexperimental researchexperimental studyexperimentsfiregrowth hormone release inhibiting factorhippocampalhuman old age (65+)implant designin vivoinhibitory neuronmechanisms in ADmechanisms in Alzheimer's diseasememory declinememory dysfunctionmolecular pathologymouse modelmurine modelnerve cell deathnerve cell lossneuralneural degenerationneural dysfunctionneurodegenerationneurodegenerativeneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossnoveloptogeneticsover 65 yearspathophysiologypathwaypathways associated with ADpathways associated with Alzheimer'spathways contribute to Alzheimer'spathways involved in Alzheimer diseasepathways that contribute to ADpathways that drive ADpathways underlying Alzheimer'sprimary degenerative dementiasenile dementia of the Alzheimer typesocial rolespatial memorystatisticstranslational neuroscience≥65 years
Description preview
Project Summary
In the US, Alzheimer’s disease (AD) is the sixth leading cause of death, affects 11% of the population over age
65, and costs $355 billion each year. One of the first impairments in AD is spatial memory, which involves the
hippocampal area CA1. CA1 encodes new information, driven by inputs from medial entorhinal cortex (MEC),
and…
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