grant
Dynamic Nanofibrous Hydrogels for Enhancing Stem Cells' Therapeutic Potency
Organization UNIVERSITY OF MIAMI CORAL GABLESLocation CORAL GABLES, UNITED STATESPosted 1 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAddressAdhesivesAdipocytesAdipose CellAffectAllogenicBasal Transcription FactorBasal transcription factor genesBehaviorBiocompatible MaterialsBiomaterialsBioreactorsBody TissuesCell BodyCell CountCell Culture SystemCell FunctionCell Growth in NumberCell MultiplicationCell NumberCell PhysiologyCell ProcessCell ProliferationCell SurvivalCell ViabilityCell surfaceCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCharacteristicsChemicalsChondroblastClinical effectivenessCo-cultureCocultivationCocultureCoculture TechniquesCollagenCollagen Type ICuesDiameterDiseaseDisorderECMElectrospinningEncapsulatedEngineeringEnsureExtracellular MatrixFat CellsFiberFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHumanHuman FigureHuman bodyHyaluronic AcidHydrazonesHydrogelsImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIndividualIntegrin BindingLengthLinkLipocytesLymphocyte SuppressionMature LipocyteMature fat cellMeasuresMechanicsMemoryMentorsMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethodsModern ManMolecularMorphologyNanotopographyOsteoblastsPhasePhenotypePlayProductionProgenitor CellsProliferatingPropertyProteinsRelaxationReportingReproducibilityResearchResearch ProposalsRoleRosalesSecretory CellSignal PathwaySourceStressStructureSubcellular ProcessSupervisionSurfaceSystemTestingTherapeuticTissuesTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationType 1 Collagenangiogenesisbiological materialbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescommercial scale manufacturingcrosslinkcytokinedensitydesigndesigningimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinsightintegrin boundmanufacturemanufacturing ramp-upmanufacturing scale-upmechanicmechanicalmechanical cuemechanical propertiesmechanical signalmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmicrobioreactornanofibernanofibrouspatient populationprogenitor cell expansionprogenitor expansionproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialscaffoldscaffoldingscale up batchscale up productionsensorsocial rolestem and progenitor cell expansionstem cell approachstem cell based approachstem cell expansionstem cell methodstem cell methodologystem cell procedurestem cell techniquestem cellssuppress lymphocytesthree dimensionalthree-dimensional modelingtranscription factorupscale manufacturingviscoelasticity
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Project Summary/Abstract
Human mesenchymal stem cells (hMSCs) are considered a source for allogeneic therapies to treat
diverse diseases. Due to the exponential increase in demand, there is a need for new strategies to produce
potent hMSCs to serve diverse patient populations. Currently, conventional planar culture and bioreactors are
used as…
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