grant
Dynamic modulation of HCN4 and ASICs
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Aug 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPASIC channelAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)Amino AcidsBindingBinding ProteinsCNG channel (rod)CNS Nervous SystemCardiac ChronotropismCell BodyCell DeathCell Membrane LipidsCell membraneCellsCentral Nervous SystemCholineCouplesCyclic AMPCyclic NucleotidesCytoplasmic MembraneDevelopmentDorsal Root GangliaDrug TargetingElementsFamilyGoalsGrantHCN4HCN4 geneHeart RateHomoHyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4Ion ChannelIonic ChannelsIonsIschemiaIsoformsLigand Binding ProteinLigand Binding Protein GeneLipid BindingLipidsMembrane ChannelsMembrane LipidsMolecular InteractionMolecular MachinesNa elementNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeuraxisNeurocyteNeuronsNeurotransmittersPainPainfulPeripheral Nervous SystemPhotobleachingPlasma MembranePlayPolyunsaturated Fatty AcidsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPropertyProtein BindingProtein IsoformsProtein ModificationProteinsRegulationResearchRoleSiteSodiumSpinal GangliaStimulusTechniquesTemperatureWorkacid-sensing ion channelsadenosine 3'5' monophosphateaminoacidbound proteincAMPcardiac pacemaker cellcationic channel protein (rod)cyclic-nucleotide gated channelcyclic-nucleotide gated ion channelsdevelopmentaldorsal root gangliondrug developmentextracellulargangliocyteganglion celllipid boundmechanical forcenecrocytosisneuronalnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnodal myocytenovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpacemaker cellplasmalemmaprotein functionsensorsingle moleculesmall moleculesocial rolestoichiometrystroke-like challengestroke-like conditionstroke-like disorderstroke-like outcomestroke-like symptomsstroke-like syndromestructural determinantsstructural factorsvoltagevoltage gated channel
Description preview
Project Summary
Ion channels are precisely tuned molecular machines that control the flow of ions across the plasma membrane.
They can sense a wide array of stimuli including voltage, pH, neurotransmitters, temperature, and mechanical
force. The function of these proteins depends critically on an array of factors that can regulate their activity…
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