grant

Dynamic Evaluation of Neural Mechanisms for Affective Touch: Pathways for Touch-induced Pleasantness and Pain Modulation

Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 3 May 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202621+ years oldAblationAddressAdultAdult HumanAffectiveAfferent PathwaysAlzheimer beta-ProteinAlzheimer's Amyloid beta-ProteinAlzheimer's amyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnalgesia TestsAnteriorAnterolateralApoplexyAreaBrainBrain Nervous SystemBrain Vascular AccidentBrain imagingC FiberCNS Nervous SystemCell Communication and SignalingCell SignalingCellular MechanotransductionCentral LobeCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalComplementary interventionComplementary therapiesComplementary treatmentComplexConduction-Blocking AnestheticsConnector NeuronCordotomyDataDeafferentationDeafferentation procedureDedicationsDependenceDiseaseDisorderEncephalonEntrapment NeuropathiesEsthesiaEvaluationFiberFunctional MRIFunctional Magnetic Resonance ImagingGoalsHealthImpairmentIndividualIndividual DifferencesInsulaInsula of ReilIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingInvestigatorsIsland of ReilLeftLightLocal AnestheticsMachine LearningManipulation TherapyManipulative TherapiesMapsMassageMechanical Signal TransductionMechanosensory TransductionMethodsMind-Body InterventionMind-Body MedicineMissionNCCAMNCCIHNational Center for Complementary and Integrative HealthNational Center for Complementary and Integrative MedicineNerve FibersNerve compression syndromeNeural PathwaysNeuraxisNociception TestsNociceptorsOutcomePainPain AssessmentPain ControlPain MeasurementPain TherapyPain managementPain measurePainfulParasympathetic Nervous SystemPathway interactionsPatientsPeripheralPhotoradiationProcessPublic HealthRelaxationRelaxation TherapyResearchResearch PersonnelResearchersRoleSensationSignal TransductionSignal Transduction SystemsSignalingSkinSomatosensory CortexSpinalStrategic PlanningStrokeStudy SubjectTactileTemperature SenseTestingTimeTouchTouch sensationa beta peptideabetaadulthoodamyloid betaamyloid-b proteinbeta amyloid fibrilbiological signal transductionbrain attackbrain visualizationcerebral vascular accidentcerebrovascular accidentchronic paincingulate cortexcompression neuropathycomputer based predictionfMRIheart rate variabilityindividual responseindividualized responseinnovateinnovationinnovativemachine based learningmanual therapymassage therapymechanosensingmechanotransductionmind body approachmind body medicine skillsmind body techniquesmind body therapymind body treatmentsmind body wellnessnerve compressionneural controlneural mechanismneural regulationneuromechanismneuromodulationneuromodulatoryneuroregulationnociceptive neuronsnovelpain assaypain interventionpain reductionpain reliefpain treatmentpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspathwaypinched nervepredictive modelingpreferencepreservationpressurereduce painrelaxation trainingrelieve painresponsesecondary outcomesocial rolesoluble amyloid precursor proteinsomesthetic sensory cortexstrokedstrokestactile sensationtemperature sensationtheoriesthermoreceptiontoolvolunteer
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Project Summary/Abstract
The exact mechanisms by which light stroking and deep pressure – components of massage therapy – induce

pleasantness and pain modulation are not understood. Given the frequent use of massage therapy for relaxation

and pain relief, and the need for complementary tools for chronic pain, there is a critical need to study the…

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